Best Anti Aging Wrinkle Creams for 2021 - The Dermatology Review

Best Anti Aging Wrinkle Creams for 2021

SKIN CARE REVIEWS

01.12.21DISCLAIMER

Who wouldn’t want to get their hands on youth in a jar? Luckily the idea isn’t a complete fantasy. While there is no such thing as a miracle wrinkle cream that can turn back time, there are plenty of products that can help with anti-aging concerns, whether that’s softening the look of fine lines, brightening up dark circles or just adding a little more glow to mature skin.

Every year new advances in skincare science bring us one step closer to achieving our best looking skin. For most of us, that means skin that looks glowing and hydrated, and where wrinkles aren’t the first thing that somebody notices on the face. Best of all, it’s not necessary to spend a fortune on effective anti-aging skincare.  Of course it’s possible to spend hundreds of dollars on department store brands, but there are plenty of drugstore picks that can pack a punch against wrinkles, along with mid-priced products. Here are our picks for the best wrinkle and anti-aging creams for every budget and every age, whether you’re a man or a woman, and in your  30’s, 40s, 50s and beyond.

What Causes Wrinkles?

Wrinkles are a normal part of the aging process. They are caused by a multitude of factors. As the Cleveland Clinic notes, as we get older the dermis (the middle layer of the skin) starts to thin. The dermis is made up of elastin and collagen which give the skin firmness and support, so as it weakens, wrinkles are more prominent. Older skin also retains less moisture and takes longer to heal, which all contribute to wrinkles. Other factors which accelerate the aging process include sun exposure, smoking, dehydration and repeated facial movements.

Best Anti Aging Wrinkle Creams for 2018

How Do Anti-Aging Creams Work?

Anti-aging creams work on multiple levels, so they are true multi-taskers but it boils down to protection, prevention and treatment. Hydration also plays a key role. A good anti-aging cream will add moisture to the skin, which instantly improves its appearance. Why? Dry, parched skin can look dull and emphasize the look of fine lines. An anti-aging day cream ideally would contain a sunscreen to help prevent damage from the sun – but if it doesn’t, it’s easy enough to add a separate sunscreen to your morning routine. And of course, night creams don’t need to contain sunscreen.

The best wrinkle creams also put the brakes on the aging process thanks to antioxidants which help prevent damage from free radicals, and ingredients which help promote and protect collagen, which is what gives skin its plump up look. Some anti-aging creams also exfoliate the skin, which help it look smoother and more even. Many contain retinol, which is the gold-standard ingredient for anti-aging (more on that below) as it helps fade the look of fine lines, discoloration and encourages collagen production.

Fighting the signs of aging doesn’t come down to one magic product. It’s also important to remember that it is easier to prevent wrinkles than get rid of them. That’s why the American Academy of Dermatology  suggests starting with a  sunscreen and moisturizer. Sunscreen should always be the first line of defense against wrinkles. The AAD suggests using a water resistant broad spectrum SPF 30 (or higher) product. The AAD also notes that “moisturizer is the secret ingredient in many anti-aging products.” How come? Skin that is well hydrated looks better. Dry skin can look papery and emphasize the look of wrinkles, while moisturized skin looks plump and dewy.

How Many Anti-Aging Products Do I Need?

There is no one single product that can solve every anti-aging concern. The best approach to skincare is a multi-prong one, using multiple types of products such as creams, serums and spot treatments. If you had to boil down an anti-aging skincare routine to the basics, it would include a moisturizer, sunscreen, serum, toner, spot treatment and night cream but it makes sense to identify the ingredients needed first to and then find the appropriate product that contains them.

Some of the best anti-aging ingredients to look for to battle wrinkles include retinols (the gold standard wrinkle fighter) along with co-enzyme Q-10, which is thought to help reduce the look of wrinkles. Vitamin C helps brighten skin and fade the look of dark spots while alpha hydroxy acids slough off dead skin cells to reveal fresher looking skin. Ceramides are also essential as they help seal moisture into the skin, and to help skin main elasticity, reach for collagen supporting creams. If you have red or inflamed skin, look for creams containing  niacinamide, a form of  vitamin B3 that helps to calm skin. 

What Should I Look for in a Wrinkle Cream?

The sheer number of wrinkle creams available can be overwhelming. Where do you even start to look? That’s easy- the packaging. 

Anti-aging ingredients include tried and true favorites as well as newer ones. Some of the newer ones making a buzz include bakuchiol, a plant-derived ingredient that is meant to work in a similar way to retinol, as well as stem cells. In face creams, they can be derived from plants or even stem cells. They contain proteins and amino acids, and send a message to the body to create new skin cells, which (in theory) could result in fresher looking skin.

According to the Mayo Clinic, the most common ingredients in anti-wrinkle creams include retinol, vitamin C, hydroxy  acids, peptides, tea extract, niacinamide (vitamin B) and coenzyme Q10. Other ingredients to look for that are prevalent in the best wrinkle creams include hydrating ingredients like hyaluronic acid and shea butter to the list, as well as vitamin C. Also look for products that contain exfoliators like glycolic or lactic acid. Exfoliating the skin helps it look smoother and more even. 

Vitamin C is thought to help protect the skin from sun damage and is also used in brightening formulas, which means it helps tackle dark spots and under eye circles. It’s commonly found in serums and creams.

Alpha hydroxy acids (AHAs) usually come from citrus and work to exfoliate the skin. Why is this important? Dead, dry skin cells can exacerbate the look of fine lines, while fresh skin tends to look smoother and softer, so it’s a key anti-aging ingredient. The Mayo Clinic notes that coenzyme Q10 may help protect the skin from sun damage, as well as help reduce fine wrinkles. The Clinic  highlights peptides as being beneficial as they may help stimulate collagen production, and have been shown to improve skin texture and wrinkling. Antioxidants like tea extract (from green and black teas) have anti-inflammatory qualities, and finally, niacinamide (or vitamin B-3) is a true multi-tasker, and helps reduce water loss and may also improve skin elasticity. But if you had to narrow down one of the most important anti-aging ingredients, it would most likely be retinol. Here’s why.

How Does Retinol Help Fight Wrinkles?

Retinol, which is derived from vitamin A, is considered the gold standard ingredient when it comes to anti-aging. It has been around since the 1970s, when it was originally used to treat acne. Patients using it for breakouts noticed a welcomed side effect- their fine lines and wrinkles were less noticeable. Today retinol is available in borth prescription and over the counter products.

According to Harvard Health Publishing, retinoids reduce fine lines and wrinkles by increasing collagen production. It also helps to fade age spots and soften rough skin patches. It takes about six to 12 months to see benefits. It is important to note that retinol use can cause dryness and irritation, so start slowly by using the product around 2-3 times a week to see how the skin tolerates it before increasing its usage.

Is a Cream or Serum Better for Anti-Aging?

If you’re wondering if you should use a cream or a serum, the answer is “both.” Serums and creams perform different functions and to get the optimal anti-aging benefit, they should be used together. A serum is lightweight, water based and quickly absorbed into the skin. Because serums don’t contain thickeners and fats like a moisturizer, they are highly concentrated- which means they deliver a big dose of skin healthy ingredients right where you need it. They are often called the workhorses of a skincare routine as they do the heavy lifting. Many people use a vitamin C- ferulic acid- niacinamide serum which helps protect the skin and give it a glow and use it before applying a cream.

What Is The Best Wrinkle Cream?

Our top anti-wrinkle creams come from a variety of brands, and at a variety of price points. We have also included some clean (and natural) beauty brands. What they all have in common is that they help improve the look of both fine lines and deep wrinkles, along with hyperpigmentation and dry skin. These anti-wrinkle creams harness the power of naturally sourced ingredients as well as the latest scientific advances to address a variety of aging issues including rough texture, dullness, dryness and, of course, all manner of wrinkles. Finding the best wrinkle cream for you may involve some trial and error.  You can feel good knowing that all of these wrinkle creams will deliver and help address the most pressing skin care issues you may have.

Best All-Around Wrinkle Creams

The best eye wrinkle cream for puffiness is Formulyst’s Lifting and Wrinkle Smoothing Cream. Followed by Carrot & Stick The Moisturizer.

THE BEST PRODUCT

1Formulyst Lifting and Wrinkle Smoothing Cream

This deeply nourishing cream was designed to help reclaim a youthful looking complexion. Formulyst’s Lifting and Wrinkle Smoothing Cream is a true multitasker. It helps lift, smooth and refine the appearance and tone of the skin. The velvety formula contains a powerful blend of lipids and botanicals that have targeted anti-aging benefits. Key ingredients include moringa seed oil for intense moisture, evodia ruteacarpa fruit to help brighten and refine, and peony extract to help skin look smoother. Over time your complexion feels firmer and looks lifted, with a radiance that can only be likened to a beautiful youthful glow

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Carrot & Stick The Moisturizer

2Carrot & Stick The Moisturizer

Say goodbye to aging skin with the plant-powered The Moisturizer. This cream does it all to deliver your best looking, radiant skin. It helps to hydrate, firm and revitalize the skin. The Moisturizer is formulated with plant proteins, vitamins, peptides and amino-collagen, along with stem cell extract from hardy alpine roses. A caffeine boost helps perk up the skin while five distinct coconut elements help with cell renewal and overall conditioning. The Moisturizer is suitable for all skin types.

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Formulyst Anti-Aging Concentrate

3Formulyst Anti-Aging Concentrate

When you want to turn back the clock against fine lines, wrinkles and sagging skin, your first line of defense should be a serum. This lightweight but powerful serum absorbs quickly into the skin and helps promote the five signs of youth – radiance, elasticity, firmness, skin tone and smoothness. The serum is powered by peptide complex along with nourishing shea butter, antioxidant green tea and vitamins C and E. Layer this serum under your wrinkle cream for best results.

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Advanced Dermatology Anti Wrinkle Firming Night Treatment

4Advanced Dermatology Anti Wrinkle Firming Night Treatment

Advanced Dermatology’s entire anti-aging skin care regimen is designed to give you the best skin of your life. The Super Youth Serum diminishes the appearance of fine lines and wrinkles while the Deep Cellular Regeneration cream regenerates skin cells to give them a new boost and further help reduce the most prevalent signs of aging. This regimen also contains an eye cream, daily cleanser and day cream to make sure all areas are covered. The Anti Wrinkle Firming Night Treatment is especially potent, working away all night to help you wake up looking refreshed. It contains hyaluronic acid, acetyl tetrapeptide-2, lactic acid and plant botanicals to help smooth away expression lines, firm up skin and restore radiance. Hyaluronic acid helps restore hydration to prevent dryness than can exacerbate expression lines. Acetyl tetrapeptide-2 helps improve both tone and texture by boosting cellular regeneration. Lactic acid is an alpha-hydroxy acid that gradually sloughs away dead skin cells to produce a glowing complexion. The plant botanicals act as antioxidants to reduce free radical damage and protect skin. Used in conjunction with the rest of the Advanced Dermatology set, this anti-wrinkle cream can potentially renew and rejuvenate skin.

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5 Clinique Repairwear Laser Focus

This anti-wrinkle serum from Clinique’s well-known anti-aging skin care line smooths out wrinkles and expression lines thanks to several key ingredients. Plant extracts, peptides and sodium hyaluronate team up to fight lines all over the face including forehead wrinkles and lip lines that are often a result of repeated expressions like frowning, smiling or smoking. The peptide acetyl hexapeptide-8 specifically targets the muscles that create these expression lines. Botanicals like clary extract and St. Paul’s wort act as antioxidants and skin conditioning agents to further address wrinkles, while sodium hyaluronate plumps up deep lines to make them far less noticeable.

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6 SkinCeuticals A.G.E. Interrupter

SkinCeuticals A.G.E. Interrupter seeks to reduce damage from advanced glycation end products, or AGEs, a result of excess sugar that negatively impacts collagen and elastin in the skin. Without collagen and elastin, skin loses firmness and elasticity, leading to sagging and wrinkling. This anti-wrinkle cream helps counteract that with potent ingredients like proxylane, blueberry extract and phytosphingosine. The proxylane helps support the skin’s own glycosaminoglycan (GAG) synthesis. GAGs like hyaluronic acid keep skin plump, firm and hydrated. Many skin disorders occur as a result of disruptions in the GAG synthesis, leading to aging problems. Blueberry extract is an antioxidant and anti-glycation agent that helps counter free radical damage. Phytosphingosine is a naturally occurring chemical that helps the skin’s barrier repair itself to keep moisture in and contaminants out. Together, these three ingredients help protect and improve skin conditions for a clearer, smoother complexion overall.

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7 Shiseido Benefiance WrinkleResist24 Day Cream

This anti-wrinkle cream relies on several plant extracts, hyaluronic acid and hydroxyproline to help prevent and reduce the appearance of wrinkles. A rich, luxurious cream, this product is formulated with chlorella, mukurossi and gambir extracts that act as antioxidants and moisturizers to reduce free radical damage and restore moisture. Hyaluronic acid retains 1,000 times its weight in water, thereby helping to bind moisture to skin. This results in a plumping effect that can help smooth out wrinkles. Hydroxyproline is an amino acid that helps synthesize collagen and helps prevent the degradation of collagen and elastin, which happens naturally as we age and as a result of sun damage. Stable collagen in the skin helps keep it firm and bouncy, retaining that snapback associated with younger skin.

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8 Elemis’s Pro-Collagen Marine Cream

Elemis’s Pro-Collagen Marine Cream promises results in as little as two weeks. This anti-wrinkle cream is formulated with algae and other plant extracts to replenish the skin with much-needed moisture. Gradual loss of moisture, as well as the breakdown of proteins like collagen and elastin, are what lead to wrinkle formation in the first place. Thus, keeping skin adequately hydrated can go a long way in preventing this from happening. Padina pavonica and chlorella vulgaris are two of the algae extracts used in this cream, both of which have antioxidant tendencies to fight off free radical damage that degrades collagen. Padina pavonica is also an emollient, meaning it keeps skin moisturized and soft. It is also thought to help improve elasticity, keeping skin firm. Other plant extracts in this rich wrinkle cream include ginkgo biloba, rose centifolia and mimosa. Ginkgo biloba is a very powerful antioxidant, while rose centifolia helps improve firmness and mimosa is believed to help stimulate collagen production

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9 Dior Capture Totale Multi-Perfection Creme

The key ingredient in this anti-wrinkle cream from Dior’s Capture Totale anti-aging skin care line is longoza, a flower from Madagascar that Dior researchers discovered approximately 20 years ago. According to the company, this ingredient revitalizes skin by boosting fibroblast, collagen and elastin production. Fibroblasts are the cells responsible for producing collagen, which helps skin look tighter and firmer. This wrinkle cream also contains emollients and antioxidants to soften and protect against free radicals. The cream is available in three options- light texture, rich texture and universal texture to accommodate a variety of skin types including sensitive, oily and dry.

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10 SK-II Power Cream

This anti-wrinkle cream from the venerable SK-II brand targets several aging concerns including loss of elasticity, dryness, wrinkles and sagging. Like most SK-II products, the main ingredient is pitera, a substance highly rich in vitamins, minerals, organic acids and amino acids to truly nourish and revitalize skin, leaving it radiant and rejuvenated as it works to fight wrinkling, UV damage and loss of firmness. Pitera is derived from a fermentation process featuring secret ingredients that also includes yeast strains. This ingredient was discovered when it was found that sake brewers had beautifully unlined, unaged hands that seemed to be directly a result of the yeast used during the fermentation process. This cream is especially recommended for dry skin as it has a very rich texture.

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11 Elizabeth Arden Prevage Anti-Aging Moisture Cream Broad SPF 30

Three key ingredients team up to provide long-lasting hydration and anti-aging benefits in Elizabeth Arden’s Prevage Anti-Aging Moisture Cream. Active ingredients include idebenone, thiotaine, retinyl linoleate, hibiscus seed extract and shea and cocoa butters. Idebenone is an antioxidant that reduces and helps prevent free radical damage that can be especially degrading to skin. Thiotaine is also an antioxidant that works to make idebenone even stronger. Retinyl linoleate is a vitamin A derivative that softens the look of fine lines and wrinkles via exfoliation. Hibiscus seed extract helps maintain the amount of collagen in the skin to keep it firm. Shea and cocoa butters are simply there to provide an adequate amount of hydration to make skin soft and smooth. This formulation also contains SPF 30 to guard against further sun damage.

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12 Dermalogica Age Smart Super Rich Repair

A thick, rich cream that still absorbs quickly, Dermalogica’s Age Smart Super Rich Repair is a great anti-wrinkle cream for anyone with dry skin. Arginine and palmitoyl tripeptide-5 discourage wrinkle formation and encourage collagen production for smooth, supple skin. Arginine helps calm the muscles responsible for creating forehead wrinkles and other lines that may form around the mouth and eyes. Plant extracts like evening primrose oil and apple seed extract act as skin conditioners and antioxidants. Apple seed extract has shown in some studies to be effective against wrinkles as well.

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13 Exuviance Evening Restorative Complex

This anti-wrinkle, anti-aging cream goes to work while you sleep to help you wake up with radiant, glowing skin. Active ingredients include vitamins A, C and E, lactobionic acid, hyaluronic acid and gluconolactone. Vitamins A, C and E serve several functions — vitamin A exfoliates to reduce the appearance of lines, vitamin C brightens the skins and lightens dark spots and also promotes collagen production, while vitamin E serves as an antioxidant to fight free radicals. Lactobionic acid is also an antioxidant that has the ability to plump and firm while also helping prevent wrinkle formation. Hyaluronic acid assists in plumping up wrinkles to smooth them out. Gluconolactone is a polyhydroxy acid that diminishes lines and wrinkles while also improving texture. It’s truly a powerhouse with ingredients that work.

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14 Kiehl’s Powerful Wrinkle Reducing Cream

Kiehl’s Powerful Wrinkle Reducing Cream is formulated with collagen boosting ingredients that get the job done. Copper PCA and calcium PCA both work with collagen to stabilize and prevent its breakdown. Copper PCA also helps increase moisture in the skin. According to Kiehl’s, elasticity can be improved by as much as 32% thanks to these ingredients. Another ingredient locking in moisture is apricot kernel oil, which softens and helps smooth out wrinkles. This wrinkle cream also contains two antioxidants, ginkgo biloba and vitamin E. A lot of aging is a result of environmental stressors like pollution and UV damage. Antioxidants are essential in countering this damage. Wrinkles and other signs of aging can thus be prevented with antioxidants.

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15 Estee Lauder Time Zone Age Reversing Line/Wrinkle Creme

Estée Lauder’s Time Zone Age Reversing anti-aging skin care products help target forehead wrinkles, lip lines and plenty of other signs of aging.  The main ingredient is the company’s Tri-HA Cell Signaling Complex. According to in vitro (in a glass or dish; not on a living organism) testing, this complex can increase the amount of natural hyaluronic acid in the skin by as much as 182%. Why is this important? Hyaluronic acid is crucial for maintaining moisture and a smooth complexion. It locks in moisture to help plump up lines and alleviate that sunken look. This wrinkle cream is ideal for normal and combination skin, and is non-comedogenic (won’t clog pores). Other moisturizing and hydrating ingredients include avocado oil and jojoba seed oil, while some wrinkle-reducing ingredients include apple fruit extract and acetyl hexapeptide-8. Several other plant extracts like grape seed, watermelon and cucumber provide antioxidant benefits.

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16 La Prairie Anti-Aging Night Cream

La Prairie is known for its luxurious formulations and this anti-wrinkle cream is no exception. The main wrinkle-fighting ingredients in this cream are peptides. Hexanoyl dipeptide-3 norleucine acetate is a synthetic peptide that helps skin cells shed better and also helps overall skin renewal, accelerating the speed at which cells renew to reveal a more refined complexion. It helps clarify skin texture to smooth out rough spots and make wrinkles less noticeable. Palmitoyl tripeptide-8 helps soothe skin by reducing inflammation. Acetyl decapeptide-3 helps stimulate collagen and elastin to make skin firmer, make wrinkles smoother and help to tighten and lift the skin. A few moisturizing ingredients include shea butter, sunflower seed oil and panthenol (a provitamin of vitamin B5).

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17 Lancome High Resolution Night Refill 3X

This anti-wrinkle cream contains several hydrating ingredients that help rejuvenate and revive aging skin. Some of the key ingredients include squalane, meadowfoam seed oil, sodium hyaluronate and hydroxypalmitoyl sphinganine. Squalane is an emollient found naturally in the skin. It is non-comedogenic, good for all skin types and efficiently hydrates to improve texture and suppleness. Meadowfoam seed oil is similar to jojoba. It is an antioxidant as well as a  moisturizer, and can strengthen the skin barrier, which helps keep pollutants and irritants out and moisture in. Sodium hyaluronate is the salt of hyaluronic acid and can retain tremendous amounts of water. It works to plump up the look of wrinkles and fine lines. Hydroxypalmitoyl sphinganine is a ceramide precursor. Ceramides keep skin soft and supple so it’s less likely to show age.

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18 Estée Lauder Revitalizing Supreme Global Anti-Aging Cream

This luxurious cream’s secret ingredient is moringa extract. The moringa plant contains nourishing nutrients like vitamin C, which helps with evening out skin tone (fading discoloration and hyperpigmentation) and promoting collagen synthesis. Collagen synthesis helps with preventing and treating wrinkle formation. Estée Lauder’s own laboratory testing found that 96% of women in the study felt they had firmer skin after just four weeks of using this moisturizer. Hydrating ingredients in this formula include sodium hyaluronate (the salt of hyaluronic acid, which can retain 1,000 times its weight in water) and squalane.

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19 Amorepacific Future Response Age Defense Crème

This moisturizer is specifically formulated to protect against pollution and free radical damage. Free radicals can degrade collagen and elastin, the two proteins in skin that keep it looking youthful. Protecting with the antioxidants in this formula, which include green tea and pine mushroom, can go a long way in preventing free radical damage. Green tea contains a powerful antioxidant known as EGCG, which prevents cell damage. Pine mushroom contains flavonoids that can neutralize free radicals. This formula also contains a fusion of twelve Asian botanicals that help reduce traditional signs of aging like fine lines.

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20 SK-II R.N.A. POWER Radical New Age Cream

Sk-II’s wrinkle cream is packed with powerhouse ingredients, including the brand’s signature RNArchitect Complex and trademarked pitera. RNArchitect Complex contains hydrolyzed soy and yeast extracts that help maintain skin firmness. Pitera is derived from yeast fermentation and contains over 50 micro-nutrients such as amino acids, vitamins and minerals that nourish and condition, making skin soft and supple. Niacinamide and chlorella extract are two other ingredients that reduce moisture loss and brighten skin, and hydrate and condition to help prevent wrinkles, respectively.

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21 Dr. Barbara Sturm Face Cream

Dr. Barbara Sturm has a cult like following for her pricey but effective products. Her Face Cream is a rich, highly moisturizing product with ingredients like panthenol, squalane and shea butter. Well hydrated skin is less likely to show wrinkles and fine lines, and these ingredients can help restore moisture loss that occurs as we age. The key ingredient in this moisturizer is Dr. Sturm’s signature purslane, an herbaceous plant that reportedly has regenerative properties. According to Dr. Sturm herself, “Purslane protects the DNA of the cells from age-related dysfunction, thereby maintaining the cells’ repair function and strengthening them with the natural antioxidant system contained in these compounds.” As noted above, antioxidants help protect against free radical cell damage..

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22 Algenist Regenerative Anti-Aging Moisturizer

Algenist’s Regenerative Anti-Aging Moisturizer relies on algae to provide a boost of hydration and anti-aging prowess. The main ingredient in this wrinkle cream is alguronic acid, which is a compound that protects microalgae in the oceans. The concept is that alguronic acid will also protect human skin cells against aging. In vitro testing of this ingredient also showed that it is effective in elastin synthesis. Elastin is a protein that keeps skin firm and elastic, helping it to bounce back. Like collagen, it is essential in keeping skin looking youthful. This moisturizer also contains vitamin C and apple stem cell extract. Apple stem cell extract has shown promise in helping to reduce wrinkle depth and length. All together, these ingredients can go a long way in revitalizing aging skin.

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23 Chanel Le Lift Crème

Chanel is known for its luxury skincare products, and this anti-aging moisturizer feels lightweight and absorbs easily into skin. Chanel’s Le Lift contains botanical alfalfa concentrate. This ingredient is considered as efficient as retinol, according to Chanel’s. Retinol, or vitamin A, is known for its ability to refine the appearance of wrinkles and even help with acne, particularly stubborn acne. It helps speed up cell turnover,which makes skin appear much more vibrant. Regular use of this cream can help skin look firmer and make wrinkles appear less noticeable by softening them.

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24 Kiehl’s Ultra Facial Cream

Kiehl’s Ultra Facial Cream is a firm fan favorite. Providing 24-hour hydration, it is formulated with glacial glycoprotein and olive-derived squalane. Glacial glycoprotein comes from glaciers. This ingredient is celebrated for its ability to thrive in extreme environments, with the idea being that it is resilient enough to be good for human skin. In this formula, it hydrates and prevents moisture loss to keep skin supple. Olive-derived squalane is a moisturizing face oil that also prevents moisture loss and protects the skin barrier. The skin barrier, when compromised, can result in redness, flakiness and dryness, making skin look exhausted and less radiant. Protecting the skin barrier is very important in maintaining a smooth and luminous complexion.

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25 La Mer Crème de la Mer

A moisturizer that needs no introduction, La Mer’s famous Crème de la Mer owes its protective powers to the Miracle Broth, which is created by fermenting sea kelp. A giant kelp called Macrofys pyrifera is the main ingredient. It is an anti-inflammatory that protects against puffiness, irritation and redness. It is also thought to assist in wound healing. This cream offers great hydration for dry skin, which shows age more readily than oily or combination skin.

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26 Olay Regenerist Micro-Sculpting Cream

The Olay Regenerist Micro-Sculpting Cream is a drugstore wrinkle cream favorite. It combines a variety of anti-aging ingredients for best results. Amino-peptides, hyaluronic acid and niacinamide (vitamin B3) work together to hydrate and firm while also reducing the appearance of fine lines and wrinkles. Amino-peptides are the building blocks of proteins in our skin and body. Collagen, the most abundant protein in the body, is what keeps skin firm and taut. Amino-peptides in creams can help maintain this firmness. Hyaluronic acid also occurs naturally in the body, helping keep skin plump and hydrated. Niacinamide, meanwhile, has a variety of benefits, including the ability to treat acne, reduce moisture loss, improve discoloration and smooth out wrinkles.

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Source: the Mayo Clinic
References:
Caberlotto, E., Ruiz, L., Miller, Z., Poletti, M., & Tadlock, L. (2017). Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles. PloS one, 12(3).
Al-Niami, F & Chiang, N 2017. ‘Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications’, The Journal of Clinical and Aesthetic Dermatology, vol. 10, is. 7, pp. 14-17.
Murray, J, Burch, J, Streilein, R, Iannacchione, M, Hall, R & Pinnell, S 2008. ‘A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provided protection for human skin against damage caused by ultraviolet radiation’ Journal of the American Academy of Dermatology, vol. 59, is. 3, pp. 418-425. 
Tang, S. C., & Yang, J. H. (2018). Dual Effects of Alpha-Hydroxy Acids on the Skin. Molecules (Basel, Switzerland), 23(4), 863. 
Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308–319.
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258. 
Tang, S. C., & Yang, J. H. (2018). Dual Effects of Alpha-Hydroxy Acids on the Skin. Molecules (Basel, Switzerland), 23(4), 863. 
Kumar, N & Pruthi, V, 2014. ‘Potential applications of ferulic acid from natural sources’, Biotechnology Report, vol. 4, pp. 86-93.

  • User Original review: Jul 21, 2020. Reply

    Some other wrinkle creams:

    Olay Regenerist Micro-Sculpting Cream
    The Olay Regenerist Micro-Sculpting Cream combines a variety of anti-aging ingredients for best results. Amino-peptides, hyaluronic acid and niacinamide (vitamin B3) work together to hydrate and firm while also reducing the appearance of fine lines and wrinkles. Amino-peptides are the building blocks of proteins in our skin and body. Collagen, the most abundant protein in the body, is what keeps skin firm and taut. Amino-peptides in creams can help maintain this firmness. Hyaluronic acid also occurs naturally in the body, helping keep skin plump and hydrated. Niacinamide, meanwhile, has a variety of benefits, include the ability to treat acne, reduce moisture loss, improve on discoloration and smooth out wrinkles.

    Kiehl’s Ultra Facial Cream
    Kiehl’s Ultra Facial Cream is a popular favorite. Providing 24-hour hydration, it is formulated with glacial glycoprotein and olive-derived squalane. Glacial glycoprotein comes from glaciers. This remarkable ingredient is celebrated for its ability to thrive in extreme environments, with the idea being that it is resilient enough to be good for human skin. In this formula, it hydrates and prevents moisture loss to keep skin supple. Olive-derived squalane is a moisturizing face oil that also prevents moisture loss and protects the skin barrier. The skin barrier, when compromise, can result in redness, flakiness and dryness, making skin look exhausted and less radiant. Protecting skin barrier is very important in maintaining a smooth and luminous complexion.

    Amorepacific Future Response Age Defense Crème
    This moisturizer is specifically formulated to protect against pollution and free radical damage. Free radicals can degrade collagen and elastin, the two proteins in skin that keep it looking youthful. Protecting with the antioxidants in this formula, which include green tea and pine mushroom, can go a long way in preventing free radical damage. Green tea contains a powerful antioxidant known as EGCG, which prevents cell damage. Pine mushroom contains flavonoids that can neutralize free radicals. This formula also contains a fusion of twelve Asian botanicals that help reduce traditional signs of aging like fine lines.

    La Mer Crème de la Mer
    A moisturizer that needs no introduction, La Mer’s famous Crème de la Mer owes its protective powers to the Miracle Broth, which is created by fermenting sea kelp. A giant kelp called Macrofys pyrifera is the main ingredient. It is an anti-inflammatory that protects against puffiness, irritation and redness. It is also thought to assist in wound healing. This cream offers great hydration for dry skin, which shows age more readily than oily or combination skin.

    Dr. Barbara Sturm Face Cream
    This cream is rich in highly moisturizing ingredients like panthenol, squalane and shea butter. Well hydrated skin is less likely to show wrinkles and fine lines, and these ingredients can help restore moisture loss that occurs as we age. However, the main ingredient in this moisturizer is purslane, an herbaceous plant that reportedly has regenerative properties. According to Dr. Sturm herself, “Purslane protects the DNA of the cells from age-related dysfunction, thereby maintaining the cells’ repair function and strengthening them with the natural antioxidant system contained in these compounds.” As previously mentioned, antioxidants help protect against free radical cell damage. Thus, this cream with its antioxidant strength can be very beneficial in protecting aging skin.

    SK-II R.N.A. POWER Radical New Age Cream
    Quite a few ingredients make up the formulation of this cream, including the RNArchitect Complex and trademarked Pitera. RNArchitect Complex contains hydrolyzed soy and yeast extracts that help maintain skin firmness. Pitera is derived from yeast fermentation and contains over 50 micro-nutrients such as amino acids, vitamins and minerals that nourish and condition, making skin soft and supple. Niacinamide and chlorella extract are two other ingredients that reduce moisture loss and brighten skin, and hydrate and condition to help prevent wrinkles, respectively.

    Estee Lauder Revitalizing Supreme Global Anti-Aging Cream
    This luxurious cream’s secret ingredient is moringa extract. The moringa plant contains nourishing nutrients like vitamin C, which helps with evening out skin tone (fading discoloration and hyperpigmentation) and promoting collagen synthesis. Collagen synthesis helps with preventing and treating wrinkle formation. Estee Lauder’s own laboratory testing found that 96% of women in the study felt they had firmer skin after just four weeks of using this moisturizer. Hydrating ingredients in this formula include sodium hyaluronate (the salt of hyaluronic acid, which can retain 1,000 times its weight in water) and squalane.

    Chanel Le Lift Crème
    Another luxurious product, this moisturizer feels lightweight and absorbs easily into skin. Chanel’s Le Lift contains botanical alfalfa concentrate. This ingredient is considered as efficient as retinol, according to Chanel’s own testing. Retinol, or vitamin A, is known for its ability to refine the appearance of wrinkles and even help with acne, particularly stubborn acne. It is great at cell turnover, helping skin to shed old cells and make new cells come to the surface, effectively making skin appear much more vibrant. Regular use of this cream can help skin feel firmer and make wrinkles appear less noticeable by softening them.

    Shiseido Benefiance WrinkleResist24 Night Cream
    This rich moisturizer quenches skin’s thirst and provides deep hydration. It relies on WrinkleResist24 technology, which includes chlorella extract, mukurossi extract and gambir extract. These are all excellent skin conditioning agents that soften and smooth, helping wrinkles look less noticeable over time. This cream also contains hyaluronic acid to help plump up wrinkles and moisturize skin, while hydroxyproline (an amino acid) also provides conditioning to make aging skin look and feel more supple. This combination of ingredients packs quite a wallop against aging skin for people in their 30s (when prevention is key) and beyond (when restoring youthfulness becomes a primary skin concern).

    Algenist Regenerative Anti-Aging Moisturizer
    Algenist’s Regenerative Anti-Aging Moisturizer relies on algae to provide a boost of hydration and anti-aging prowess. The main ingredient in this cream is alguronic acid, which is a compound that protects microalgae in the oceans. The thought process behind this is that alguronic acid will also protect human skin cells against aging. In vitro testing of this ingredient also showed that it is effective in elastin synthesis. Elastin is a protein that keeps skin firm and elastic, helping it to bounce back. Like collagen, it is essential in keeping skin looking youthful. This moisturizer also contains vitamin C and apple stem cell extract. Apple stem cell extract has shown promise in helping to reduce wrinkle depth and length. All together, these ingredients can go a long way in revitalizing aging skin.

  • User Original review: Jul 21, 2020. Reply

    If we all had two options, aging naturally or aging slowly, when it comes to the exterior—the skin—most of us would choose the latter. That’s why there are hundreds of skincare products meant to slow down wrinkles and sagging, including moisturizers for aging skin over 50 years old.

    Related: Best Face Moisturizers

    But what’s the best wrinkle cream on the market? Start with ingredients, including vitamin C, hyaluronic acid, peptides and niacinamide, which have been well researched and offer results. These ingredients exist in many of the moisturizers on this list, which is why they were selected. Take a look and you’ll find something right for you.

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