22 of the Best Anti-Aging Face Serums for Your 30s and Beyond

One of the most vital skincare products in any routine is an anti-aging serum. Applied after cleansing and toning and before moisturizing, a serum is a step that should not be skipped or overlooked. Why? A serum’s molecular size is significantly smaller than a moisturizer or other skincare product formulations, meaning potent, results-driven ingredients can penetrate on a more profound and practical level. 

Most face serums for anti-aging are multi-taskers, addressing more than one skin issue, including wrinkles, discoloration, loss of tone, and poor texture. They also provide vital antioxidant protection against environmental stressors (pollution, sun) exacerbating the aging process.

With that said, this is the best face serum is one of the most effective anti-aging treatments, regardless of how old you are. After all, the best anti-aging defense method is prevention.

Even so, there’s a big difference between your average face serum for anti-aging and the best wrinkle serum. Not sure where to start? No worries. Here at the Derm Review, we’ve reviewed hundreds of products with a scientific lens to ensure you’re creating a skincare regimen that’s safe and effective. Ahead, 22 of the best anti-aging serums to help address environmental assault and the natural aging process.

Best Anti-Aging Serum: The List

Carrot & Stick The Repair Serum, $80

Formulyst Anti-Aging Concentrate, $125

The Ordinary Buffet, $11.40

Tula Skincare Hello Radiance Illuminating Serum, $68

Avène A-Oxitive Antioxidant Defense Serum, $44

First Aid Beauty Retinol Serum .25% Pure Concentrate, $58

Neutrogena Hydro Boost Hydrating Hyaluronic Acid Serum, $23.99

ZO Skin Health Vitamin C Self Activating, $93

Formulyst Anti-Aging Concentrate, $125

Estée Lauder Advanced Night Repair Serum, $75

Clinique Smart Custom-Repair Serum, $62

Kiehl’s Hydro-Plumping Re-Texturizing Serum Concentrate, $100

Murad Retinol Youth Renewal Serum, $89

Dr. Dennis Gross C + Collagen Brighten and Firm Vitamin C Serum, $80

La Roche-Posay Pure Retinol Face Serum with Vitamin B3, $39.99

Kate Somerville +Retinol Vitamin C Serum, $98

Formulyst Ultimate Youth Concentrate, $129

Strivectin Advanced Hydration Lactic Acid Nightly Retexturing Serum, $79

Olay Regenerist Max Tone Serum With Vitamin C, $32.99

Lancôme Advanced Génifique Anti-Aging Face Serum, $105

Sunday Riley A+ High Dose Retinoid Serum, $85

RoC Retinol Correxion Deep Wrinkle Serum, $24.99

What to Look for in the Best Anti-Aging Serum 

Sure, you can consider celebrity endorsements, glowing editorial reviews, and dermatologist recommendations (which are not always approved, by the way). Still, when shopping for the best anti-aging serum, it’s always a good idea to do your homework. We’ve put together some easy tips to help you take the guesswork out of finding the best face serum to defy visible signs of aging effectively.

The Best Anti-Aging Serum Ingredients

The first step is to choose an anti-aging serum with a cocktail of the best evidence-based anti-aging ingredients on the market. When it comes to the best serums for anti-aging, Elle, our in-house biochemist, suggests:

• Retinol
  Derived from vitamin A, retinol is the gold-standard ingredient for the best anti-aging serum. It encourages skin cell turnover, which means skin looks smoother and firmer. While most anti-aging skincare products work on a topical level at the epidermis, retinol works at a cellular level. This means it penetrates deep into the dermis, speeding up cell turnover and stimulating collagen production to help your body generate smoother, plumper, revitalized skin. Not only does retinol help new wrinkles from forming, but it also treats the ones you already have, making it a vital ingredient in the best serum for aging skin.

• Hyaluronic Acid
  Hyaluronic acid is an aqueous substance that our bodies produce naturally to help maintain the skin’s moisture. While HA is found in our connective tissue, joints, and even eyes, we’re here to discuss hyaluronic acid concerning the skin.We produce less of it as we age, resulting in increased dryness, fine lines, and wrinkles. For this reason, hyaluronic acid in skincare is incredibly beneficial. As it’s a humectant, it can hold over 1,000 times its weight in water, so it’s safe to say it’s a super-hydrator of epic proportions — and an excellent addition to the best wrinkle serum.

• Vitamin C
  While several antioxidants have an anti-aging effect on the skin, vitamin C tops the list. It protects your skin from elements like the sun (though it is not a replacement for sunscreen), pollution, and cigarette smoke. Vitamin C also discourages melanin production in the skin, which helps with discoloration and increases radiance. It’s a popular ingredient in the best serum for aging skin.

• Bakuchiol
  Bakuchiol is touted as a gentle, vegan alternative to retinol products, helping reduce the signs of aging (fine lines, wrinkles, dullness) while supporting the treatment of acne and congested skin.

• Alpha Hydroxy Acids
  Alpha hydroxy acids are water-soluble acids derived from fruits with high sugar content. AHAs are derived from fruit acids that dissolve dead skin cells and produce a peeling action that helps fade pigmentation and scarring, improves texture and tone, and softens fine lines and wrinkles.

• Peptides
  Peptides for the skin have numerous benefits, making them one of the most attractive anti-aging serum ingredients. Peptides are incorporated into skincare products like the best anti-aging serums because of their performance-specific effects, such as hydration, improved skin tone, and other anti-aging benefits, such as reducing age spots, fine lines, and wrinkles.

The Concentration of Ingredients in the Best Wrinkle Serum

Here’s the thing: Just because an anti-aging serum is formulated with the ingredients mentioned above doesn’t necessarily mean it’s going to fight Father Time. It’s not only what’s in the serum that matters; it’s how much of it, too. 

For example, a brand may claim its product is formulated with vitamin C — but maybe it’s only at a rate of 1%. If that’s the case, it’s not going to affect your skin. However, if it was at a rate of 15%, you’ve got yourself an effective anti-aging serum.

While some brands make it easy for you to determine the concentration of ingredients, many others make you work for it — but you don’t need to be a chemist. Follow these basic guidelines to help take the guesswork out of the process. 

• Ingredient Order: The ingredients that make up most of the formula are at the top of the ingredient list, and the less active ones are towards the end. So, if you see the “supposed” active ingredients the brand is marketing towards the bottom of the ingredient label, it’s a potential red flag. Remember, the first ingredient on the list is typically the carrier that delivers the active ingredients into the skin — it’s typically water. Most anti-aging serums are made up of approximately 70% water.
• Concentration — But Not Always: One exception to this rule is that concentration isn’t always everything. Some active ingredients only need .5 to one percent to be the most effective, and because so little of the active ingredient is required, it goes at the end of the list. A few actives, like salicylic acid and retinol, work well even at low concentrations (<2%).
• How Active Ingredients are Listed: Fortunately, the FDA requires active ingredients designated as drug ingredients to be explicitly listed separately on product packaging. These labels are sometimes required to include the strength of these ingredients.
• Ingredients 1% or Less May Be Listed in Any Order: Any ingredient used in a concentration of 1% or less, meaning it can be listed in random order. This can be tricky because you’re likely not going to know which of those ingredients start at the 1% mark (or less) on the list. Again, keep in mind that some actives can fall into this category, but it doesn’t mean they’re not effective. 
• Keep an Eye Out for Filler Ingredients: Filler ingredients can trick into thinking a product is more natural or well-formulated than it is. Some brands promote copious extracts and botanicals, and while they’re both great ingredients, they’re often in such a low concentration and merely marketing-speak. 

How it’s Packaged

Multiple studies suggest that consumers are drawn to colorful, fancy, or innovative cosmetic packaging. However, when choosing the best anti-aging serum, you shouldn’t base it on looks. Not only is it what’s inside that counts, but anti-aging products are made with ingredients that need to be protected to prevent oxidation and decreased efficiency. 

• Packaging with non-airtight pumps is not a good choice — especially for ingredients like retinol, vitamin C, and peptides. 
• Airless packaging is a packaging or dispensing system that doesn’t allow air to contact the product, thus maintaining its integrity and efficiency. It’s one of the latest user-friendly design methods brands are turning to. One of the latest reports from Global Market Outlook indicates airless packaging accounted for $4.3 billion of the market in 2017 and is expected to reach $7.7 billion by 2026
• When shopping for a serum with antioxidants like vitamin C or retinol, avoid transparent glass or plastic bottles because they destroy the efficiency of the product. Formulations with these ingredients should be packaged in dark, opaque bottles (dark glass is a good choice) that block out UV light that can deactivate them. 
• Buyer beware. If serums are yellow or brown, that might mean the manufacturers added a tint to hide oxidation.
• While it’s not uncommon to see serums packaged in bottles with medicine droppers, they’re not ideal for supersensitive ingredients, like vitamin C. Brands often gravitate to droppers because they evoke the feeling of a professional treatment. The reality is, this application method causes the serum to expire more quickly. 
• There are a lot of packaging innovations out there today that do a great job of preventing air and light from destroying the formula. If a brand is using one, they’ll likely let you know. 

Are the Best Anti-Aging Serums More Expensive?

While it’s true that serums for anti-aging tend to be one of the more expensive products in your skincare routine due to their supposed high concentration of ingredients, it’s a misconception that a more expensive serum always works better. It all comes down to quality ingredients, effective concentration, and the science behind it — one of our areas of expertise here at the Derm Review. 

How to Get the Most out of Your Anti-Aging Serum 

You’re investing in the best anti-aging serum, so you want to get the most out of it, right?  

• Cleanse Thoroughly: While it should go without saying, start with a clean canvas before applying your serum. After washing your face, rinse with tepid — not hot or cold water. Hot water could inhibit the absorption of the serum, while cold water will close pores, making it more difficult to penetrate. 

If you don’t typically wash your face in the morning (and assuming you don’t sleep with your makeup on), at least make sure you’re sweeping a cotton pad saturated with micellar water, essence, or toner suitable for your skin type. 

• The Damp Skin Debate: Many experts say that applying a serum to damp skin can increase its efficiency up to ten times. While this is true, this rule does not apply to all ingredients like actives such as vitamin C, retinol, and exfoliating acids — all of which can be found in many anti-aging serum products. 
• Less is More: Since serums are super concentrated, you only need a few drops — no more than the total size of one pea — for your entire face and neck. Any more product and it’s a waste of your money.  Press the serum into your skin with an open palm to release active ingredients. 
• Wait to Moisturize: Yes, you need a serum and a moisturizer, but wait until your serum fully absorbs (about two to three minutes) before moisturizing. A well-formulated serum will absorb quickly into your skin. If it leaves an oily or sticky residue, it’s not doing its job.

Anti-Aging Serums by Age

Your 30s

Your 30s are an excellent time to get serious about establishing a solid skincare routine. Whatever you were doing in your 20s isn’t going to cut it anymore. Between intrinsic (chronological) and extrinsic (lifestyle) aging factors, your complexion may be looking more tired and dull than usual. 

Due to hormonal fluctuations from pregnancy or stress, those teenage breakouts may be making another appearance. Of course, looking in the mirror and noticing fine lines, uneven skin tone, and volume loss can catch you off guard, too. 

Your 40s 

When you move into the 40s decade, more significant changes start to pop up. Whether you notice discoloration, loss of elasticity and volume, or fine lines and wrinkles, your 40s are a time to reevaluate how you’re taking care of your skin so you can tweak your skincare routine — serum included.

Your 50s

Even though reaching the half-century mark is a significant milestone, your 50s is when a whole new crop of changes you may not be prepared for starts to appear. We’re talking about thinner skin, more prominent wrinkles, crepiness, more sunspots, and a change in texture. Additionally, the skin doesn’t heal as quickly, and it’s more susceptible to free radical damage.

Best Anti-Aging Serums

Carrot & Stick The Repair Serum, $80
Apply this serum daily to keep skin hydrated and protected from free radical damage. The Repair Serum by Carrot & Stick helps lift, tighten and firm the look of skin thanks to seven plant-based neuropeptides, while synthesized growth factors help keep skin looking its radiant best.

Formulyst Anti-Aging Concentrate, $125
Formulated with ProBioBalance and a powerful Peptide Complex, this fast-acting multitasker of a super serum harnesses the natural skincare benefits of Shea Butter, Green Tea & Vitamins C+E to visibly promote the five signs of youth – radiance, elasticity, firmness, skin tone and smoothness.

Easily absorbed yet intensely rich, this highly concentrated formula conditions your complexion and diminishes the appearance of age spots, wrinkles and fine lines. Leaving you with skin that feels silky smooth and a complexion that looks bright and radiant after every use. It’s also free from parabens and fragrances. 

The Ordinary Buffet, $11.40
The Ordinary Buffet formula combines a comprehensive array of studied technologies to target multiple signs of aging at once. The key ingredients — or “technologies” as the brand calls them — in The Ordinary Buffet include Matrixyl 3000, Matrixyl synthe ‘6, SYN-AKE, Argirelox, and a probiotic complex. These technologies are formulated in a base of 11 skin-friendly amino acids and multiple hyaluronic acid complexes to target multiple signs of aging while also improving skin hydration.

Related: Best Hyaluronic Acid Serums

Tula Skincare Hello Radiance Illuminating Serum, $68
This popular hydrating serum gives the skin a noticeable from-within glow every day. It’s formulated with light-reflecting pearlescence to instantly illuminate the skin, while Japanese mandarin brightens lackluster skin over time. Additionally, rice peptides firm the skin, and prebiotic and probiotic extracts balance and nourish. 

Avène A-Oxitive Antioxidant Defense Serum, $44
This lightweight, fast-absorbing serum promises to defend the skin against the most challenging environmental stressors. It is formulated with popular antioxidant ingredients vitamin C and E, and it provides superior antioxidant protection while improving the skin’s appearance. It works to smooth the skin’s texture while reducing the appearance of fine lines and brightening the complexion.

First Aid Beauty Retinol Serum .25% Pure Concentrate, $58
When it comes to retinol, everyone has to start somewhere. This formula is perfect for newbies, as well as those with sensitive skin. It contains a mere .25% strength of retinol, skin-plumping peptides, and First Aid Beauty’s proprietary “Skin Saver Complex” (hyaluronic acid, aloe vera, colloidal oatmeal, ceramides, allantoin, and vitamins C and E.) The result? Nourished skin alleviated from any irritation that’s traditionally linked to retinol.

Neutrogena Hydro Boost Hydrating Hyaluronic Acid Serum, $23.99
This popular serum for 30s, aging skin is formulated with Neutrogena’s 17% Hydration Complex made of high and low weight hyaluronic acid, vitamin B5, and trehalose to attract moisture and seal it in. All skin types will feel weightlessly hydrated for a total of 24 hours.

Related: Best Hydrating Serums

ZO Skin Health Vitamin C Self Activating, $93
This ZO Skin Health Vitamin C serum combines 10% ascorbic acid (pure vitamin C) with tetrahexyldecyl ascorbate (a stable vitamin C derivative). This anti-aging serum also includes vitamin E, which can become more powerful when combined with vitamin C. For this reason, vitamins C and E are referred to as “network antioxidants” to brighten, hydrate, and firm the skin.

Formulyst Anti-Aging Concentrate, $125
This anti-wrinkle serum is packed with powerhouse ingredients to help skin look healthy, vibrant, and younger. Formulyst’s Anti-Aging Concentrate is formulated with ProBioBalance, and powerful peptide complex, moisturizing shea butter, antioxidants green tea, and vitamins C and E. These skin-loving ingredients work together to help promote radiance, elasticity, firmness, skin tone, and smoothness. The serum is rich but absorbs quickly into the skin and helps soften the look of fine lines, wrinkles, and dark spots.

Estée Lauder Advanced Night Repair Serum, $75
First introduced in 1982, Advanced Night Repair Serum was the first anti-aging night serum in the industry. Today, nearly eight bottles are sold every minute. Thanks to humectants, emollients, probiotics, soothing botanicals, and a peptide, this anti-aging formula is said to address signs of aging caused by the environmental assaults of modern life — like pollution, blue light, and environmental toxins.

Related: Best Night Serums

Clinique Smart Custom-Repair Serum, $62
If you feel as though your 40s skin is changing from one day to the next, you’ll love this high-tech serum that adjusts to suit the needs of anyone who wears it. It targets, treats, and prevents specific skin issues, whether that’s loss of elasticity, fine lines, and wrinkles, dryness, dullness, breakouts, and hyperpigmentation — basically anything that can pop up in your 40s. The secret sauce is a blend of brightening botanicals, vitamin C, peptides, and salicylic acid.

Kiehl’s Hydro-Plumping Re-Texturizing Serum Concentrate, $100
This unique serum features Japanese shiso, which prevents the degradation of hyaluronic acid — another ingredient in this formula — to deeply hydrate while improving the skin’s elasticity. Glycerin and an epidermal hydration filler encourage the skin’s natural production of hyaluronic acid to enhance dullness while smoothing the appearance of fine lines and an uneven texture.

Murad Retinol Youth Renewal Serum, $89
This power-packed serum is formulated with two forms of retinol—one that works quickly and another that’s time-released—to soften fine lines and wrinkles and even out the skin tone while stimulating collagen production. A retinol booster enhances the results, while hyaluronic acid minimizes dryness and promotes a from-within glow.

Related: Best Retinol Serum

Dr. Dennis Gross C + Collagen Brighten and Firm Vitamin C Serum, $80
While technically, vitamin C is vital for collagen synthesis, this serum takes it to another level with the addition of collagen amino acids. There’s also lactic and mandelic (a form of alpha hydroxy acid) acids to dissolve dead skin cells and a proprietary Energy Complex (CoQ10, superoxide dismutase, carnitine, and niacinamide) to boost radiance, improve firmness, and diminish the appearance of pigmentation spots over time.

Related: Best Niacinamide Serums

La Roche-Posay Pure Retinol Face Serum with Vitamin B3, $39.99
While many French brands choose the more “au naturale” side, that doesn’t mean every product is restricted to pure essential oils and extracts. This serum from La Roche-Posay is formulated with gradual release retinol to prevent irritation. Glycerin hydrates and vitamin B3 prevent water loss and soothe. You’ll see instant gratification via a luminous complexion, but signs of aging are reduced over time.

Related: Best Face Serums

Kate Somerville +Retinol Vitamin C Serum, $98
It’s not too often that you see a serum incorporating retinol and vitamin C because they thrive in two different pH environments. However, Kate Somerville has managed to formulate a serum that harnesses both of these power-packed ingredients. It works while you sleep to brighten, tone, and revive a dull, uneven skin tone. Clinical studies indicate that 97% of users noticed improved fine lines and wrinkles after just one use. After one week, 93% saw an improvement in skin elasticity, and 90% said their skin tone looked brighter.

Related: Best Vitamin C Serums

Formulyst Ultimate Youth Concentrate, $129
As we age, our ability to produce Epidermal Growth Factors (EGF) falls, resulting in the key signs contributing to aging skin. Yet at the forefront of skincare formulation is Formulyst’s Ultimate Youth Concentrate. Bioengineered from plant stem cells and loaded with a potent combination of five unique peptides, this profoundly hydrating anti-aging serum visibly increases your skin’s youthful suppleness, softening the appearance of fine lines and wrinkles.

Strivectin Advanced Hydration Lactic Acid Nightly Retexturing Serum, $79
As the name suggests, this formula is one of the best serums for targeting dry, lackluster skin because it exfoliates one of the keys to achieving a supple, plump complexion. Alpha-hydroxy acids, vegan lactic acid, blue cypress oil, and an advanced youth-boosting Nonapeptide boost the skin’s natural moisturizing factors while improving skin tone and texture.

Olay Regenerist Max Tone Serum With Vitamin C, $32.99
You’ll find vitamin B3 in a lot of Olay products (they call it “their unicorn”) because it increases cell turnover, promotes a vibrant complexion, and deeply hydrates. Along with niacinamide, this power-packed serum is formulated with brightening vitamin C and a proprietary Skin Energizing Complex to make skin look and feel smoother and more radiant and youthful. 

Lancôme Advanced Génifique Anti-Aging Face Serum, $105
Lancome’s supercharged serum is packed with ingredients to keep skin hydrated and increase cell turnover and is designed for older skin. One of its key ingredients is Bifida ferment lysate, a bacteria that is similar to a probiotic for the skin and helps boost the skin’s moisture barrier. Hyaluronic acid also adds moisture to the skin, while a dose of vitamin C helps it look brighter. There’s no need to worry about whether you’re applying the right amount; the dropper is self-loading.

Sunday Riley A+ High Dose Retinoid Serum, $85
Full disclosure: This is not a retinol serum for rookie retinol users. This professional strength formula consists of a 5% retinoid ester blend, 1% liposomal-encapsulated retinol, and blue-green algae to provide antioxidant protection. The addition of encapsulated CoQ10 works to improve damaged or aging skin; and if you’re worried about irritation due to the strength, cactus extract, Hawaiian white honey, bisabolol, and ginger calm and soothe.

RoC Retinol Correxion Deep Wrinkle Serum, $24.99
Everyone loves a good drugstore buy — especially one that’s about the effectiveness and not fluff. Formulated with RoC’s award-winning retinol, this serum is clinically proven to make the skin look ten years younger in as little as four weeks. Of course, that all depends on your age and the current state of your skin — but this serum wouldn’t be on the best-of list if it didn’t visibly produce noticeable results, especially over time.

Best Anti-Aging Serum: The Bottom Line

Overall, the best anti-aging serums are Carrot & Stick’s The Repair Serum and Formulyst’s Anti-Aging Concentrate and Pro-Collagen Serum.

Applied after cleansing and toning and before moisturizing, one of the most vital skincare products in your daily routine should be a serum — especially if it’s an anti-aging formula. Whether you’re just starting to notice the first signs of aging or you’re looking to embark on an effective skincare routine later in life, consider the best anti-aging serum as an anchor. 

Be mindful of the best active ingredients — including concentration level — packaging, the application process, and the realization that you’re not going to see results overnight — especially without consistent use.

Remember, you don’t always need to spend a lot of money to see results. Focus on quality ingredients — including concentration level — packaging, and science.