What is Argireline?

Argireline, also known as acetyl hexapeptide-3 or acetyl hexapeptide-8, is a synthetic six amino acid peptide used in anti-aging skin care products to reduce the appearance of fine lines and wrinkles. 

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How does Argireline work?

Argireline is a fragment of SNAP-25 (a substrate of botulinum toxin). It works by limiting the ability of neurotransmitters to activate movement in your facial muscles, for example, when forming facial expressions such as smiling or frowning. By inhibiting the nerves that cause facial muscles to contract, subtle facial expressions are limited and wrinkles are subsequently reduced.

What are the Best Skin Care Products of 2024?

Argireline has also been shown to promote collagen production. Collagen is a protein that is responsible for keeping the skin strong, firm, and youthful. As we age, the body produces less and less collagen. In fact, after the age of 20, a person produces about 1 percent less collagen in the skin each year. Moreover, environmental free radicals (from things like excessive sunlight exposure, smoking, pollution, etc.) can degrade collagen proteins. The result is skin that becomes thinner and more fragile with age. By promoting collagen production, Argireline may be able to increase skin firmness. 

Benefits of Argireline for skin

Studies have shown that Argireline improves the appearance of facial areas prone to developing dynamic folds, including around the eyes and in the forehead area. According to a study published in the International Journal of Cosmetic Science, when Argireline is used at a 5% concentration it has the ability to decrease wrinkles up to 30% when applied once daily for 28 days. Thus, anyone looking to smooth out wrinkles caused by repeated muscle movement in areas such as the forehead and around the eyes may benefit from topical application of Argireline. 

Is Argireline safe?

Since Argireline is a fragment of SNAP-25 (a substrate of botulinum toxin), you may be wondering: is Argireline safe? Currently, there are no known Argireline side effects. Like many peptides, Argireline does not penetrate deep into the skin because it is a large, complex molecule. Since Argireline is not absorbed into the skin, it is unlikely to cause allergic reactions. Even so, it is still important to perform a patch test on a small area of skin when trying out a new skin care product. 

The best peptide skin care products

After reading about all the benefits of Argireline for skin, you might be interested in trying a skin care product with this powerful peptide. If so, check out our top five picks for the best Argireline skin care products. 

Carrot & Stick The Repair Serum
Collagen helps boost elasticity and firmness. But the collagen molecule is too large to absorb into the skin. This where peptides come in. Our favorite peptide product is Carrot & Stick The Repair Serum. It contains 7 plant-based peptides to promote smoother skin.

Instantly Ageless Facelift in a Box
Instantly Ageless Facelift in a Box is an anti-wrinkle microcream that is claimed to instantly and visibly reduce the appearance of fine lines, wrinkles, puffy eyes, and dark circles. This cream can actually help you to notice instant results due to the presence of sodium silicate and magnesium aluminum silicate. Magnesium aluminum silicate adds bulk to the wrinkle while sodium silicate lifts the wrinkle. The end result is an instantly smoothed wrinkle. However, these ingredients produce temporary results which last for several hours or until you wash the product off. But Instantly Ageless Facelift in a Box may actually be able to give you long term results thanks to the presence of Argireline in this cream. 

Venofye ViperLift Bio Syringe
Similar to Instantly Ageless Facelift in a Box, the Venofye ViperLift Bio Syringe provides an instant (but temporary) reduction in the appearance of wrinkles due to the combination of sodium silicate and sodium polystyrene sulfonate. Fortunately, this serum does contain quite a few ingredients that provide long term benefits to the skin, including Argireline and DMAE. DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine, a neurotransmitter. DMAE works by helping the underlying facial muscles to contract, thus tightening the skin and increasing skin firmness. Other beneficial ingredients in the Venofye ViperLift Bio Syringe include cucumber fruit extract, hyaluronic acid, retinyl palmitate, tocopheryl acetate (vitamin E ester), and avocado oil. 

Good Molecules Super Peptide Serum
Good Molecules Super Peptide Serum is an anti-aging serum that is said to hydrate, brighten, and smooth for a healthy, youthful-looking glow. There are three peptides in this formula: acetyl hexapeptide-8 (Argireline), acetyl octapeptide-3, and copper tripeptide-1. Since we’ve already discussed the benefits of Argireline for skin, let’s briefly cover what the other peptides in this formula can do for your skin. Acetyl octapeptide-3, also known as SNAP-8, is a synthetic peptide based around octapeptide-3 that works in a similar way to Argireline. Copper tripeptide-1 is categorized as a messenger peptide because it works by sending messages or signals to cells, which is known as cell-signaling. For instance, when collagen is degraded it produces peptides that signal skin cells to generate more collagen. Synthetic peptides used in skin care products, such as copper tripeptide-1, can mimic these naturally occurring peptides, thus causing your skin to “think” collagen is deteriorating. This results in new collagen production. Over time, increased collagen levels promote firmer skin with less fine lines and wrinkles.

Formulyst Anti-Wrinkle Peptide Serum
One of the best Argireline serums on the market right now is Formulyst Anti-Wrinkle Peptide Serum. This serum stands out from the rest because it combines the powerful wrinkle-reducing effects of Argireline with five additional rejuvenating peptides to help smooth the appearance of fine lines and wrinkles. In addition, this formula contains hydrating ingredients like glycerin, chondrus crispus extract, and sodium hyaluronate. All of these ingredients draw moisture into the skin in order to maintain hydration while simultaneously giving the skin a more plump appearance. Ultimately, Formulyst’s Anti-Wrinkle Peptide Serum helps to smooth the appearance of fine lines and wrinkles – leaving skin looking and feeling smoother, stronger, and radiantly more youthful.



Carrot & Stick

Carrot & Stick takes a tough love approach to skincare. What does this mean? It perfectly balances the power of plants with innovative science, offering the best of both worlds. Read More


The philosophy of Formulyst is long-term and effective skincare, rather than covering up any imperfections. The comprehensive line of products tackles everything from wrinkles to dark spots and dry skin. While some brands rely on unnecessary fillers and scents, Formulyst focuses on ingredients that help create results, such as vitamins, minerals and antioxidants. Read More

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