Magnesium Gluconate - The Dermatology Review

Magnesium Gluconate



Magnesium gluconate is an ingredient used in skin care products that delivers the important essential mineral magnesium to the skin. Magnesium provides many benefits to the skin, such as helping to reduce acne and soothing sensitive skin.


Magnesium gluconate is the magnesium salt of gluconic acid, a carboxylic acid that is produced by the fermentation of carbohydrates. Gluconic acid occurs naturally in fruit, honey, and wine. Magnesium gluconate shows the highest level of bioavailability of any magnesium salt. It is available as an oral supplement used to prevent and treat low amounts of magnesium in the blood.

Magnesium has several important roles in the human body. It is a cofactor for more than 300 enzymatic reactions and it is vital for adenosine triphosphate (ATP) metabolism. In addition, magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Magnesium also regulates muscular contraction, blood pressure, insulin metabolism, cardiac excitability, and nerve transmission.


In cosmetics and personal care products, magnesium gluconate provides several benefits, such as helping to reduce acne and soothing sensitive skin.

Magnesium gluconate can be found in skin care products intended to prevent and treat acne because magnesium can inhibit the overproduction of sebum. Sebum is a naturally occurring oily substance that moisturizes, lubricates, and protects the skin and hair. Even though sebum production is normal, when it is produced in excess it can clog the skin’s pores. Clogged pores then lead to acne breakouts. There are numerous factors that can increase the skin’s sebum production, including cosmetics, smoking, stress, foods and drink with high sugar content, and many more. Research indicates that magnesium can break apart different fats and oils, thus reducing the oiliness of the skin. For this reason, magnesium gluconate is an effective ingredient for the prevention and treatment of acne.

Magnesium gluconate is also used in skin care products intended to treat redness, irritation, and sensitive skin because magnesium has a calming effect on the skin. Topical magnesium gluconate has been found to reduce stress-related skin irritations, such as acne and rosacea.

Topical magnesium gluconate is also used to replenish magnesium levels in the body. Replenishing magnesium levels has several health benefits, including reducing inflammation, promoting relaxation, relieving muscle aches and pains, healing small cuts and scrapes, increasing energy, and drawing toxins from the body. Low levels of magnesium also affect receptors and neurotransmitters that cause migraine headaches. Therefore, topical magnesium may help to reduce migraines.

Lastly, magnesium gluconate may have an anti-aging effect on skin due to its role in protein synthesis. Although magnesium does not directly produce collagen, it does play a role in the synthesis of proteins that ultimately become collagen. Collagen is the most abundant protein in the human body. It is the major component of connective tissues that make up several body parts, including tendons, ligaments, muscles, and skin. Collagen plays a role in strengthening skin, plus may benefit elasticity and hydration. After the age of 20, a person produces about 1 percent less collagen in the skin each year. Moreover, environmental free radicals can degrade collagen proteins. Ingredients that help to replenish collagen, such as magnesium gluconate, can help maintain the skin’s strength and firmness.


The safety of magnesium gluconate has been evaluated and rated on EWG’s Skin Deep Cosmetic Database. According to the Cosmetic Database, magnesium gluconate is rated as a 1 on a scale of 1 to 10, with 1 being the lowest risk to health and 10 being the highest.

References: “Magnesium for skin: why it’s the best acne and wrinkle fighting supplement” 2016, “Sebum” 2018, Nutrients 2017 Aug; 9(8): 813, Dr. Axe “Magnesium Oil Benefits — from Sports Performance to Migraine Relief” 2018, EWG’s Skin Deep Cosmetic Database “Magnesium Gluconate”

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