Ethylparaben - The Dermatology Review




Ethylparaben is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.


Ethylparaben is the ethyl ester of p-hydroxybenzoic acid. It is a member of the class of compounds known as parabens. Other common parabens include methylparaben, butylparaben, isobutylparaben, and propylparaben. At one time, parabens were the most widely used group of preservatives in cosmetic products. The reason why parabens were so popular is due to their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives.

Another advantage of parabens is that they are naturally derived from plants. Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens in order to protect the plant. In fact, the parabens used in cosmetics are identical to those found in nature. If parabens are absorbed through the skin, the human body can quickly metabolize them to PHBA and eliminate them. However, the use of parabens is now controversial due to their alleged relation to health concerns, which we will discuss below.


Ethylparaben functions as a preservative in cosmetics and personal care products. In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%. The use of preservatives is necessary to prevent microbial contamination, as well as to prevent degradation by environmental factors such as heat, light, and air.

Cosmetics have a high potential for microbial contamination and growth. The most susceptible products are creams and lotions that are packaged in jars, opened frequently, and applied to the skin with the fingers. Inadvertent contamination may also occur after the use of makeup brushes around the eyes or other parts of the face that touch the skin and the cosmetic repeatedly. Each use increases the chance for contamination. Furthermore, contamination may occur if the consumer leaves a product container open for an extended period of time.

Another major cause of product contamination is storage conditions. Since the majority of products are stored at room temperature, the warm temperature can stimulate the growth of microorganisms. Plus, the ingredients used in cosmetic formulations, such as water, oils, peptides, and carbohydrates, create the perfect environment for microorganism growth.

Microbial contamination can lead to significant health problems, from skin irritation to infections. To avoid these problems, a strong yet non-irritating preservative must be added to the formulation of a product. Ethylparaben fits boths of these criteria.


Over the past 10 years, parabens have become criticized for use in cosmetics due to research that has revealed their potential relation to health concerns. However, the research on parabens is conflicting and polarizing.

For instances, some research indicates that parabens are safe as used in cosmetics and preferred since they are gentle, non-sensitizing, and highly effective. Furthermore, these studies have demonstrated that parabens did not have any effect when compared to natural hormones in the body. In fact, parabens were found to be beneficial due to their ability to deter the growth of mold, fungi, and other harmful pathogens.

Other research has concluded that parabens are problematic. The concern started when a 2004 study linked parabens in deodorant to breast cancer. This link seemed plausible since parabens can mimic human estrogen and it is known that high estrogen levels stimulate the growth of cancer cells. However, the study has since been discredited and the American Cancer Society has concluded that there is insufficient scientific evidence of parabens increasing breast cancer risk. Furthermore, a 2005 study published in the journal Critical Reviews of Toxicology concluded that, “it is biologically implausible that parabens could increase the risk of any estrogen-mediated endpoint, including effects on the male reproductive tract or breast cancer.”

Overall, the cosmetics industry has determined that the low levels of parabens used in cosmetics and personal care products is safe, and the evidence linking parabens to breast cancer and other health concerns is insufficient. The United States Food and Drug Administration (FDA) finds that while parabens can mimic estrogen, the actual effects of this low level of activity on the body do not cause cancer in a higher incidence than naturally occurring estrogen.

References: Wikipedia, “Ethylparaben”, J Appl Toxicol. 2004 Jul-Aug;24(4):301-3, Crit Rev Toxicol. 2005 Jun;35(5):435-58, American Cancer Society, “Antiperspirants and Breast Cancer Risk”.


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