Cholesterol - The Dermatology Review

Cholesterol

ARTICLE

09.28.18 AD DISCLOSURE

Cholesterol is an organic molecule that is added to cosmetics and skin care products for its functions as a skin-conditioning agent and an emulsifier.

Origin

Cholesterol can be classified as a sterol, a type of lipid molecule. It is biosynthesized by all animal cells and has also been isolated from plants. Cholesterol is an essential structural component of all animal cell membranes, functioning to maintain both membrane structural integrity and fluidity. It is also a metabolic precursor for the biosynthesis of steroid hormones, bile acid, and vitamin D. Cholesterol is one of the most widely studied naturally occurring organic compounds.

Most cholesterol-containing products will simply say ‘cholesterol’ on the ingredient label. However, this ingredient can also be listed as either wool extract or lanolin extract (cholesterol is commonly derived from both). Additionally, cholesterol of vegetable origin is primarily derived from squalene, which is a precursor for the synthesis of cholesterol in plants.

Formulations may contain concentrations of up to 5 percent cholesterol, but the majority of products have a cholesterol content of 0.1 to 1 percent. Cholesterol is primarily used in skin care products, eye and face makeup, hair care products, and shaving preparations.

Function

To better understand the functions of cholesterol as an ingredient in skin care products, its first important to explain the natural function of cholesterol in our skin. You’ll find cholesterol as a natural component of the stratum corneum, the skin’s outermost layer. The stratum corneum is often referred to as the skin’s natural barrier, which is also comprised of corneocytes, ceramides, and free fatty acids. Ceramides represent about 50 percent of the skin’s lipid layer, cholesterol about 25 percent, and other fatty acids making up another 10 to 15 percent.

A strong, intact barrier is important to keep moisture in and keep things like allergens, bacteria, and irritants out. When the barrier is weakened, these intruders can pass through the top layer of skin, causing damage that ultimately leads to common skin conditions such as acne, rashes, sensitive skin, and even signs of aging.

Since the skin’s natural barrier consists of cholesterol, this ingredient helps maintain proper barrier functioning by retaining moisture levels and regulating cell activity. It works to strengthen the outer structure of the skin and protect it from dehydration. Cholesterol also functions to repair skin that has been stripped of its natural lipids by things like exfoliating or applying an aggressive anti-aging treatment.

Due to its ability to strengthen and repair the skin’s natural barrier, those with delicate, sensitive, and dry skin types will likely benefit most from cholesterol-containing products. Furthermore, since cholesterol levels in the stratum corneum decrease with age (approximately 40 percent by age 40), using cholesterol-containing products on aged skin could be very beneficial.

Another function of cholesterol is to act as an emulsifier by keeping the water and oil parts of an emulsion from separating, generally forming w/o (water-in-oil) emulsions. According to EFEMA, when water and oil are mixed together and vigorously shaken, a dispersion of oil droplets in water – and vice versa – is formed. When shaking stops, however, the two phases start to separate. To address this problem, an emulsifier like cholesterol can be added to the system. Cholesterol forms a monomolecular layer around the emulsion droplet, which helps the droplets remain dispersed and produces a stable emulsion.

It’s important to note that topically applied cholesterol will not have an impact on blood cholesterol.

Safety

The safety of cholesterol in cosmetics and personal care products has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that cholesterol was safe as presently used in cosmetic products. In 2004, as part of the scheduled re-review of ingredients, the CIR Expert Panel considered available new data on this ingredient and reaffirmed the above conclusion.

The EU Cosmetics Directive permits cholesterol to be used in cosmetic products, so long as it complies with the animal-by-products regulations.

Clinical studies to evaluate the safety of topically applied cholesterol were conducted with products formulated with the ingredient. Most products were moisturizers containing 1.4 percent cholesterol. The cholesterol-containing products were minimal to mild primary and cumulative skin irritants but not sensitizers or photosensitizers.

References: Wikipedia, “Cholesterol”, CIR, “Final Report on the Safety Assessment of Cholesterol”, 1986, Shape, “Why Cholesterol Is the New Best Thing for Your Complexion”, 2016, Curr Allergy Asthma Rep. 2008 Jul; 8(4): 299–305, Get the Gloss, “Do You Need Cholesterol in Your Skincare Products?”, 2017, Truth in Aging, “Cholesterol”, EFEMA, “What is an emulsifier?”, Cosmetics Info, “Cholesterol”.

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