Replenix Review



Replenix Skin Care is manufactured by Topix Pharmaceuticals, a leading manufacturer of private label skin care products. Topix Replenix is an innovative, antioxidant based anti aging range that has numerous patent pending formulas. The Topix Replenix Research and Development department is located at their FDA-approved facility in Amityville, NY. Its worthwhile noting that most skin care products are developed by private label manufacturers, however, Topix Replenix has in-hour R&D and manufacturing resources, which gives them a unique advantage over most skin care brands. In fact, Topix Pharmaceuticals manufactures on behalf of many well known skin care brands and has been in business for over 20 years.

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The Topix Replenix skin care range features 15 products, including: Replenix Fortified Cleanser, Replenix All-trans-Retinol Smoothing Serum 3X, Replenix Retinol Plus Smoothing Serum 10X, Replenix All-trans-Retinol Smoothing Serum 3X, Replenix All-trans Retinol Smoothing Serum 2X,  Replenix, All-trans-Retinol Smoothing Serum 3X, Replenix All-trans Retinol Smoothing Serum 2X, Replenix CF Cream, Replenix All-trans-Retinol Eye Repair Cream, Replenix Retinol Plus Smoothing Serum 5X and Replenix Retinol Plus Smoothing Serum 10x. We evaluated the earlier mentioned products, however, we spent much more time using the Replenix Retinol Plus Smoothing Serum 10x and found this to be one of the most exceptional retinol creams available on the market. Topix Replenix has shared before and after photos on its website and these results were consistent with what our test patient experienced.

Choosing the right skin care product is one of the most important parts of any beauty routine, well, anybody over 30 who isnt blessed with perfect looking skin. It is also one of the most difficult decisions you’ll need to make as there are hundreds of products – all claiming to be the best – and the wrong choice will not only guard against aging but certain ingredients can accelerate aging. Do these products work? We put Replenix to the test.Replenix’s primary active ingredients are Polyphenol Isolates – potent antioxidants derived from green tea. However, Replenix also utilises retinol is most of its product. Our favorite product in the range is Replenix Retinol Plus Smoothing Serum 10X. This is one of the most potent retinol treatments available right now.  If you have not used retinol based product or have sensitive skin, we recommend starting with Replenix Retinol Plus Smoothing Serum 5. If your skin does not react after a few applications, you can consider upgrading to the higher concentration serum. Whilst the cost of the product is $84, a little goes a long way, making it affordable in the long term.

Replenix product are available from Dermstore, SkinStore, SkinCare RX, LovelySkin, Dermatologist RX, Dr Bailey Skincare, Skin1 and skin clinics across America. Replenix products can be purchased directly from the Topix Replenis website. Replenix products include soothing cleansers, moisturizing lotions, treatment serums, eye creams and sun protection products. Prices vary from $20-120. Replenix products have been featured in InStyle, WH Beauty, Allure Magazine and Real Simple Magazine.



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  • Janis Original review: Apr 18, 2017. Reply

    I am 58 yrs old and have tried EVERYTHING. My dermatologist gave me Replenix and I am sold. I will never again waste my money on any other product again. Removes wrinkles, firms and smoothes. I have used it for 1 year and love love love it. I look 45 now.

  • sursattie Original review: May 13, 2014. Reply

    I have never use it but just read the reviews, i am interested in trying it. Replinix retinol smoothing serum 10x. Thanks.

  • Susan Original review: Feb 23, 2014. Reply

    Hello – I would like to sample the replenix 10x retinol if this offer is still available. Thanks!

  • Elizabeth Original review: Feb 11, 2014. Reply

    I’ve been pleased with products from the Topix Glycolix brand and would be interested to sample the Replenix products, if still available. Thanks!

  • Michelle T Original review: Dec 05, 2013. Reply

    Hello, I was contemplating going to the dermatologists to get a retinol based serum. I would like to sample The REPLENIX 10X retinol. Thank you for your gratuitous nature.


  • Toots Original review: Dec 02, 2013. Reply

    Hello, I am a 58 year old female.
    I use many different skin care brands but I have stuck with one when it comes to Retinol.
    I am a loyal user of Replenix All-trans-Retinol Smoothing Serum 3X. It’s a potent form of retinol and it does not cause all that much irritation.
    I have not tried other Topix Replenix products and I was recommended this product by a friend who has tried many different retinol based products.

  • Lucy Original review: Oct 26, 2013. Reply

    I live in North Dakota and we get very dry air in winter. I have dry skin and concerned with wrinkles and uneven skin tone. I have some age spots. I start my regimen with Replenix Gentle Antioxidant Soothing Cleanser and apply the Topix Replenix All-trans-Retinol Smoothing Serum 3X aftewards. At night I also use Replenix Dermal Restructuring Therapy. They are all good products.

  • Mimi Original review: Oct 09, 2013. Reply

    I use the topix replenix retinol smoothing serum and green tea serum. Both are brilliant products. I use the strong retinol product. The lighter one doesn’t do anything. I know the results from retinol are only short acting but I like the the way my skin looks when I use it. I think its the irritation in the retinol that causes the skin to become thicker. I wonder if it is inflammation that is causing the wrinkles to appear less visible. Maybe it is not but it sure looks good short term.

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    Replenix Sheer Physical Sunscreen Cream SPF 50 Review

    The Replenix Sheer Physical Sunscreen Cream SPF 50 was designed to give users the best of both worlds when it comes to sun protection. Sun protection on its own it’s incredibly complicated, depending on the country of origin, UV filters and overall formulation. This can make finding the right sunscreen feel exhausting and overwhelming. Good news is, that you can get the most important aspects of a product by looking at their description. For example, looking at the Replex Sheer Physical Sunscreen Cream SPF 50+, you can tell quite a bit from the title alone. As a physical sunscreen, this product uses physical filters like titanium dioxide and zinc which form a physical barrier on the skin. These filters tend to work best for those with sensitive skin types, although they can be a little bit more prone to feeling greasy or leaving behind a whitecast. With that said, these modern formulations are really beginning to eliminate that stereotype with advanced technologies and formulations that are just as light, airy and easy to apply as those with chemical formulations.


    Replenix Brightening Boost Review

    Replenix Brightening Boost is a hydrating, lightweight pigment correcting cream that is said to improve visible discoloration and brighten skin tone. One of the key ingredients in this cream is hexylresorcinol, a synthetic skin-lightening agent that can be used to control hyperpigmentation. Hexylresorcinol improves hyperpigmentation through inhibition of tyrosinase. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color. By inhibiting tyrosinase, hexylresorcinol helps to reduce abnormal pigmentation associated with aging and exposure to UV light. Hexylresorcinol also stimulates antioxidant activity (i.e. glutathione, glutathione peroxidase, and glutathione reductase). Antioxidants limit oxidative damage caused by free radicals, the unstable molecules that contribute to the formation of premature wrinkles and fine lines on the skin.

    There are two more ingredients in the Replenix Brightening Boost that work by inhibiting the activity of tyrosinase, arbutin and arctostaphylos uva-ursi leaf extract, which are both derived from the common bearberry plant. This formula also contains Morus alba (mulberry) bark extract, which is also a rich source of arbutin. A final key ingredient in the Replenix Brightening Boost is hexanoyl dipeptide-3 norleucine acetate, a synthetic peptide that helps skin’s surface shed properly and speeds up surface renewal. It works by competing with proteins on the skin’s surface that, when damaged, can prevent exfoliation. Ultimately, this peptide helps to refine skin’s appearance by smoothing the surface so it’s better able to reflect light and also maintain hydration, leading to fresher, brighter looking skin.


    Replenix Power Of Three Cream Review

    Replenix Power of Three Cream is an antioxidant rich treatment cream that contains an impressive amount of green tea extract; enough to equal 500 cups of tea! The green tea extract in this cream contains 90% polyphenol isolates, which are said to diminish the appearance of fine lines, wrinkles, and pores while calming inflammation. The main polyphenol in green tea is epigallocatechin gallate (EGCG). It functions as an antioxidant by limiting oxidative stress caused by free radicals, the unstable molecules that contribute to the formation of premature wrinkles and fine lines on the skin. In addition, green tea-derived caffeine stimulates circulation as it boosts the entire formula’s efficacy. Another powerful antioxidant in this formula is resveratrol, a natural compound found in high amounts in the skins of grapes and in red wine.

    Replenix Power of Three Cream also includes a high concentration of squalane. Your skin contains its own version of squalane known as squalene (note the e). Squalene is the biochemical precursor to cholesterol and the whole family of steroid hormones in the human body. It is produced by the oil glands in the skin, and plays an important role in skin lubrication and protection. However, the amount made and retained in the skin decreases over time. It peaks in our teens and then starts to decline in our 20’s, leaving skin rough, dry, and vulnerable. Since squalene is very unstable, squalane is used in skin care products because it is a saturated and stable hydrocarbon that mimics squalene and helps to replenish the skin’s barrier. Lastly, Replenix Power of Three Cream provides you with several skin-soothing ingredients, such as cucumber fruit extract, bisabolol, and chamomile flower extract, which should help to calm inflammation and reduce redness.


    Replenix Pure Hydration Hyaluronic Acid Serum Review

    Replenix Pure Hydration Hyaluronic Acid Serum is a quick-absorbing face serum for tight, dry skin that continually draws moisture from the air, so your skin stays hydrated throughout the entire day. In addition, the natural hydration is said to plump your skin, refining the surface of your complexion. This serum contains sodium hyaluronate, the salt form of hyaluronic acid. Sodium hyaluronate is an exceptional ingredient for adding hydration to the skin. It draws in moisture from the environment and can hold up to 1,000 times its weight in water. Sodium hyaluronate also helps to plump skin and reduce signs of aging. Another ingredient in the Replenix Pure Hydration Hyaluronic Acid Serum that addresses signs of aging is palmitoyl tripeptide-28. In-vitro studies have found palmitoyl tripeptide-28 to have a matrikine-like effect that stimulates the synthesis of collagen I, II, IV, fibronectin, hyaluronic acid, and laminin 5. Ultimately, this results in skin that appears more firm and youthful.

    Replenix Pure Hydration Hyaluronic Acid Serum contains three different salt forms of PCA (pyrrolidone carboxylic acid), including sodium PCA, zinc PCA, and copper PCA. PCA is a component of the skin’s natural moisturizing factor (NMF). The NMF can become depleted with age and also from routine exposure to sensitizing ingredients like drying cleansing agents and denatured alcohol. This leads to visibly dry, tight-feeling, flaky skin. Using ingredients that replenish the NMF, such as these salts of PCA, can improve the skin’s hydration. Lastly, Replenix Pure Hydration Hyaluronic Acid Serum provides protection against free radicals with antioxidants from white tea extract, ergothioneine, and glutathione.


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