Epionce Review



It’s not uncommon for dermatologists to develop their own line of skin care products, which is exactly the story behind Epionce. What sets Epionce apart is that founder Dr. Carl R. Thornfeldt, a clinical dermatologist, has spent over 20 years researching and developing ingredients to help heal and soothe irritated skin.

To further set his brand apart from the rest, Dr. Thornfeldt became a pioneer in demanding high quality, thorough testing on market-ready products for cosmetics.

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He believed that it was imperative for the Epionce skin care products to be backed by the kind of clinical studies he would expect to see as a physician. 

In fact, the Epionce Renewal Facial Cream paired with the Lytic Tx were the first non-prescription products to take on the top retinoids in head-to-head clinical studies.

The results of these studies were pretty impressive – the study participants and physician investigators saw the same anti-aging results, but without irritation reactions often associated with retinoid use. In this review, we’re going to discuss these two best selling Epionce skin care products, as well as key ingredients, Epionce reviews from real customers, and more. 

What are the best selling Epionce skin care products?

The Epionce product line includes such items as cleansers, toners, lotions, masks, face and body lotion, skin barrier creams, and medicated cream for skin that is injured or inflamed. Those who want to build a skin care routine from the company’s products can follow the recommended four-step system that includes products to cleanse, correct, renew, and protect the skin. Or you can try one of the best selling Epionce skin care products, such as the Renewal Facial Cream, Lytic Tx, and Medical Barrier Cream. 

Epionce Renewal Facial Cream is the flagship Epionce product. This rich moisturizing cream is said to help reduce the visible appearance of fine lines, wrinkles, and other signs of skin aging, as well as improve clarity and radiance. As mentioned above, the Epionce Renewal Facial Cream is clinically proven to provide better visible anti-aging results than leading retinoids when used with Epionce Lytic Tx.

Epionce Lytic Tx is a moderate-strength chemical exfoliant for normal to combination skin that is said to help cleanse pores while smoothing the visible appearance of skin texture and imperfections. In addition, daily use helps reduce irritation associated with blemishes and redness. 

Epionce Medical Barrier Cream is designed for those with very sensitive, dry skin types, including visibly red and irritated skin that is scaly and dry. It is said to be optimal for delicate and compromised skin that is resistant to sensitizers and preservatives found in standard moisturizers.

What are the key Epionce ingredients?

The Epionce products sound like they can truly improve the health of skin based on the product descriptions, but in order to determine whether these products really do what they say, we must look at the Epionce ingredients. 

Both the Epionce Renewal Facial Cream and the Epionce Medical Barrier Cream include petrolatum as the highest concentration ingredient (after water). Petrolatum, also known as petroleum jelly or Vaseline, is an occlusive agent that reduces the rate of water loss through skin. Since petrolatum has a melting point that is close to body temperature, it softens upon application and forms a water-repellant film around the applied area.

This film prevents evaporation of the skin’s natural moisture and increases skin hydration by causing buildup of water in the stratum corneum (the outermost layer of skin). Furthermore, petrolatum has been shown to penetrate deeply into damaged skin and enhance recovery of the skin’s barrier function. Maintaining a strong, intact barrier is important to keep harmful things like allergens, bacteria, and irritants from entering the body through the skin. 

The active ingredient in Epionce Lytic Tx is 2% salicylic acid, a type of beta hydroxy acid (BHA). Since it is lipid soluble, salicylic acid easily enters the pore, where it exfoliates the pore lining and loosens clogged dirt and oil. It also has the ability to dissolve keratin, the protein that acts as a “glue” to keep dead skin cells together in the stratum corneum.

This is effective because dead skin cells can build up on the surface of your skin, leaving it looking dull and also possibly clogging pores. Overall, the inclusion of salicylic acid in Epionce Lytic Tx means that this product should work well for those with acne-prone skin and for those with dullness. 

The final key Epionce ingredient we’d like to discuss is meadowfoam seed oil, which is used in high concentrations in the Epionce Renewal Facial Cream and the Epionce Medical Barrier Cream. Meadowfoam seed oil can help to balance oil production because it closely resembles human sebum. It has a medium to light skin feel that absorbs very quickly without feeling greasy.

It can form a protective film on the surface of skin that locks in moisture and delivers nutrients to the skin. 

Where are Epionce skin care products sold?

Epionce skin care products are sold on the brand’s website. The only authorized internet resellers of Epionce in the United States are:,,,,,,,,, and Epionce products found through internet resellers such as eBay, Amazon, Walmart, Sears, Craigslist or have no relationship whatsoever with the company and are not authorized resellers. 

What is the Epionce return policy?

Only products purchased from may be returned for refund or exchanged. If you wish to return an item(s) from your online order, you must download, complete, and email the Return Form to [email protected] explaining your reason for return. 

Is Epionce cruelty free?

Epionce is cruelty free. Episciences, Inc. does not use animal testing for any of their skin care products, either directly or indirectly.

Our Verdict

A physician formulated brand with formulas that balance  function with experience. 


  • Solid science
  • Anti aging focus
  • Mostly paraben and sulfate Free


  • Excessive ingredients in each formula that can irritate skin


What Are Some Alternatives??

If you’re looking for skincare products to address the signs of aging, we recommend Carrot & Stick. Carrot & Stick maximizes the use of powerful ingredients and minimizes the use of superficial ones, resulting in advanced skincare.



Carrot & Stick

Carrot & Stick takes a tough love approach to skincare. What does this mean? It perfectly balances the power of plants with innovative science, offering the best of both worlds. Read More


The philosophy of Formulyst is long-term and effective skincare, rather than covering up any imperfections. The comprehensive line of products tackles everything from wrinkles to dark spots and dry skin. While some brands rely on unnecessary fillers and scents, Formulyst focuses on ingredients that help create results, such as vitamins, minerals and antioxidants. Read More

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Epionce MelanoLyte Pigment Perfection Serum Review

Epionce MelanoLyte Pigment Perfection Serum is a botanical-based product formulated to help brighten and correct the visible appearance of dark spots on the face and body without irritation. It does not contain hydroquinone or any type of retinoid. Rather, this formula includes many botanical ingredients that brighten the skin through inhibition of tyrosinase, such as mulberry root extract, yarrow extract, lady’s mantle extract, mallow extract, and more. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color and also contributes to the formation of undesirable dark spots. Therefore, by inhibiting tyrosinase, these botanical extracts may be able to reduce abnormal pigmentation associated with aging and exposure to UV light.

Epionce MelanoLyte Pigment Perfection Serum also contains turmeric root extract. The bright orange-yellow color of turmeric derives from its active component, curcumin. Curcumin is a potent anti-inflammatory agent and also has antibacterial properties. Curcumin is known to provide protective effects against skin-damaging chemicals and environmental pollutants. In addition, research has demonstrated that curcumin inhibits tyrosinase activity, as well as the expression of melanogenesis-related proteins in human melanocytes. One drawback with Epionce MelanoLyte Pigment Perfection Serum is that it contains a high concentration of alcohol, which is well known to cause skin dryness, irritation, and even disruption of the skin barrier, especially when used in high concentration


Epionce Intensive Nourishing Cream Review

If you’re looking for a daily moisturizer that offers a little bit more substance for those with extra dehydrated and dry skin types, you may want to try something like the Epionce Intensive Nourishing Cream. Like the name would suggest, this cream contains high levels of rich emollients and several occlusives to help draw and keep moisture in the skin while other actives work to reduce the appearance of fine lines and wrinkles. As an ultra-rich cream, this product can be used on the face, neck and decollete for an intense dose of moisture. The brand recommends that you use this product as a night cream for the most regenerative benefits, but you can also use this product in the morning in order to get the most out of their soft focus technology which has been included to boost radiance in the skin. Additionally, we would recommend this product to those with extra dry skin. For those with combination or oily skin types, you may find that this product is too rich for your skin to handle on an everyday basis.


Epionce Intense Defense Serum Review

Epionce skin care specializes in creating cosmetic formulations that are backed by clinical studies and extensive scientific research. Their Intense Defense Serum has been advertised as a complete multivitamin for you skin. This serum contains vitamins A, B, C, D and E for healthy, happy looking skin. All of the vitamins that are provided within the serum have been gathered from botanical sources. Although this product is mostly intended to nourish your skin with essential vitamins, minerals and nutrients, the brand also states that this serum can provide an array of anti-aging results as well including reduced appearance of fine lines and wrinkles.


Epionce Renewal Facial Cream

Epionce Renewal Facial Cream: Overview and Ingredient Information Epionce Renewal Facial Cream is formulated to fight the signs of aging by reducing the appearance of fine lines and wrinkles and improving skin tone. This cream is one of many products offered by the company, which was founded by a dermatologist who focused his skin research on understanding the behavior of the skin barrier and its relation to overall skin health. Epionce Renewal Facial Cream is also formulated with this research in mind, as it believed to strengthen the skin barrier, according to the manufacturer. This product may benefit those who want to add a formula to their skin care kit that specifically targets aging. Epionce Renewal Facial Cream is available throughout the United States and the company does not ship to Canada or to international addresses at this time.

Epionce Renewal Facial Cream Price and Purchasing Information

Epionce Renewal Facial Cream can be purchased directly from the company website, by calling the company’s toll-free number, or through a number of authorized online retailers. If this is your first time buying this brand, keep in mind that the claims that are made about clinical trials concerning Epionce Renewal Facial Cream should not be the only factor that affects your purchase. You should also take the time to read Epionce Renewal Facial Cream reviews on other sites so you can discover how the product has worked for others.


Epionce Medical Barrier Cream

Epionce Medical Barrier Cream: Ingredients, Usage, and Pricing Epionce Medical Barrier Cream is formulated to protect hyper-sensitive, damaged, or irritated skin. The cream is one of many skin care products offered by this company, which focuses on skin care that stems from protecting and nourishing its natural barrier from the environments. Epionce Medical Barrier Cream may benefit those who find other products that are formulated to treat eczema or dry and irritated skin too harsh. As with many of the other products in the Epionce lineup, this intensive moisturizer was formulated with the assistance of Dr. Carl R. Thornfeldt, the founder of the company. Epionce Medical Barrier Cream is currently available for purchase only in the United States.

Epionce Medical Barrier Cream Price and Purchasing Information

Epionce Medical Barrier Cream is available in two sizes, 2.5 ounces and 8.0 ounces, and can be purchased directly from the company website. While there are no Epionce Medical Barrier Cream reviews on the site, you may be able to find them on authorized sites that also sell the product.


Epionce Lytic Gel Cleanser

Epionce Lytic Gel Cleanser: Overview, Ingredients, and Uses Epionce Lytic Gel Cleanser is formulated for oily or acne-prone skin and is designed to remove cosmetic products, dead skin, and excess oil from the top layers of the skin so that pores are left clear. This gel may suit those who use a medicated facial wash for their skin and want a product in their skin care kit to prepare their skin and open up pores so that medications for acne work more effectively. Epionce Lytic Gel Cleanser is marketed by Episciences, Inc., which was founded by Dr. Carl R. Thornfeldt, a dermatologist who has spent nearly a quarter of a century studying how the health of the skin barrier affects its overall well-being. The company’s lineup also includes a number of products for cleansing, improving skin tone, reducing the signs of aging, and reducing hyperpigmentation. Epionce Lytic Gel Cleanser is available for shipping in the U.S. only.

Where to Buy Epionce Lytic Gel Cleanser

Epionce Lytic Gel Cleanser is available for purchase directly from the company website and from other authorized online dealers. The product comes in a 6.0 ounce pump tube and is not available in any other sizes.


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