Advanced Clinicals Review



Brand background

Advanced Clinicals is a “problem-solving” skin care line that was originally developed by chemists who wanted to create effective formulations using advanced technology. The brand’s mission is to offer skin care solutions at attainable prices for their customers, which is why all Advanced Clinicals skin care products retail for under $20. Knowing that advanced treatments for anti-aging, general skin care, as well as niche problem areas, like stretch marks and age spots, were often associated with a high price tag, Advanced Clinicals made it a priority to combat this with cost-effective, large-sized solutions in easy-to-dispense packaging. Advanced Clinicals is formulated in their own lab and manufactured in their own FDA-inspected facility in Chicago.

What are the Best Skin Care Products of 2022?

Key products

Currently, Advanced Clinicals offers 50 different skin care products, including creams, lotions, oils, serums, problem-solvers, masks, and skin care for men. In this section, we’ll discuss three of the most popular Advanced Clinicals skin care products: Collagen Skin Rescue Lotion, Coconut Oil Moisturizing Cream, and Retinol Advanced Firming Cream. 

Advanced Clinicals Collagen Skin Rescue Lotion is a body and face moisturizer that is said to help promote soft, plump skin with consistent use. To use, apply a sufficient amount of lotion onto cleansed face, neck, and hands. Gently massage into skin using upward circular motions, paying special attention to the wrinkles, until fully absorbed.

Advanced Clinicals Coconut Oil Moisturizing Cream is a body and face moisturizer that is said to nourish and renew dull, parched skin for deep hydration. This cream absorbs quickly and does not leave a greasy feeling. Apply a generous amount onto cleansed face, neck, and hands. Gently massage into skin using upward circular motions, paying special attention to wrinkles.

Advanced Clinicals Retinol Advanced Firming Cream is a body and face moisturizer that is said to reduce the visible signs of aging as it helps replenish your moisture barrier. This retinol cream is gentle enough to be used daily. 

Key formulation

In order to find the formulation details for Advanced Clinicals skin care products, we had to search third party websites because the brand does not list the product ingredients on their website. Below we’ll discuss the formulation details for each of the key products mentioned above. 

Advanced Clinicals Collagen Skin Rescue Lotion contains a high concentration of mineral oil. Mineral oil is a clear, odorless oil derived from a mineral source, typically a distillate of petroleum, that functions as an emollient. After application, mineral oil forms a protective film on the surface of skin that helps to prevent evaporation of the skin’s natural moisture. Another key ingredient is hydrolyzed collagen. The term “hydrolyzed” means that the collagen protein has been broken down into amino acids so that this ingredient can better penetrate the skin. Hydrolyzed collagen is thought to replenish collagen levels in the skin that become depleted with age and from exposure to free radicals that degrade collagen. The result is skin that appears more firm and plump.

As the name implies, one of the key ingredients in the Advanced Clinicals Coconut Oil Moisturizing Cream is coconut oil. Coconut oil is an occlusive emollient, which means it forms a layer on the surface of skin to help lock in moisture. The fatty acids in coconut oil also help to replenish the skin’s barrier function. Lastly, the lauric acid found in coconut oil has antibacterial properties, which may be helpful for those with acne. Other beneficial ingredients in Advanced Clinicals Coconut Oil Moisturizing Cream include Aloe vera leaf juice, mineral oil, chamomile extract. 

Like the other two Advanced Clinicals moisturizers, the Retinol Advanced Firming Cream contains a high concentration of mineral oil to help keep the skin soft and smooth. This anti-aging cream also includes pure retinol. Retinol has the capability of minimizing the appearance of fine lines and wrinkles, improving uneven skin tone, restoring skin firmness, and shrinking the appearance of enlarged pores. Retinol provides all of these benefits by first being converted to retinoic acid (its active form) after being absorbed into the skin. Retinoic acid also functions as an antioxidant and helps the skin combat free radicals, the unstable molecules that contribute to the formation of premature wrinkles and fine lines on the skin. 

We’d like to point out one safety issue with Advanced Clinicals products: the brand uses the preservative DMDM hydantoin in several of their products. DMDM hydantoin is an antimicrobial formaldehyde releaser preservative that some consider to be unsafe because of the formaldehyde. While it has been approved safe by the Cosmetic Ingredient Review Expert Panel, this ingredient can cause irritation or an allergic reaction on sensitive skin.

Advanced Clinicals Reviews

It appears that Advanced Clinicals only includes a select few reviews on their website, and only positive reviews for that matter. For example, Advanced Clinicals reviews for the Retinol Advanced Firming Cream say things like “better than Neutrogena” and “Holy crap this stuff is GREAT.” Similar to their lack of transparency with the product formulations, it appears that Advanced Clinicals does not want to display all customer reviews for their products. 

What are some alternatives to Advanced Clinicals?

After reviewing Advanced Clinicals product formulations, we have come to the conclusion that these products are actually pretty far from “advanced”. They use beneficial yet standard ingredients in their product formulations, and the products lack new or unique ingredients. If you are searching for truly advanced skin care treatments formulated based on ground-breaking research and cutting-edge technology, we recommend Formulyst

All Formulyst skin care products are formulated to maximize the use of powerful ingredients that visibly benefit your skin and minimize the ingredients that might make you smell and feel nice, but don’t actually work. One example is Formulyst’s Anti-Aging Night Cream with Retinol. Rather than using standard retinol, the formula contains innovative Encapsulated Retinol Technology in order to deliver a higher concentration of retinol to your skin for intense rejuvenation. In addition, this night cream helps to lock in moisture and restore the skin’s barrier function with emollients such as squalane, macadamia seed oil, and jojoba oil. 

There’s no need to compromise when it comes to finding skincare that is effective and safe. Carrot & Stick takes a tough love approach to skincare, perfectly balancing the power of plants with cutting edge science. Not only is Carrot & Stick good for your skin, it is also good for the environment as the formulas skip harmful chemicals commonly found in skin care products.



Carrot & Stick

Carrot & Stick takes a tough love approach to skincare. What does this mean? It perfectly balances the power of plants with innovative science, offering the best of both worlds. Read More


The philosophy of Formulyst is long-term and effective skincare, rather than covering up any imperfections. The comprehensive line of products tackles everything from wrinkles to dark spots and dry skin. While some brands rely on unnecessary fillers and scents, Formulyst focuses on ingredients that help create results, such as vitamins, minerals and antioxidants. Read More

Advanced Clinicals Collagen Skin Rescue Lotion Review

A hydrating face and body lotion formulated with Glycerin, Aloe and Mineral Oil. The product also contains hydrolyzed collagen (also known as collagen hydrolysate), which is typically derived from animal by-products. We This product is affordable and can be purchased at Walmart, Seas and Jet.
  • Heather Original review: Apr 06, 2021. Reply

    I started using Advanced clinicals Vitamin c cream and some of their serums and I love them! They improve my skin but don’t break me out or dry me out. I have very sensitive skin and these products work well for me. Also they are inexpensive.

  • meryem Original review: Jan 25, 2021. Reply

    i got across advanced clinicals just by chance and i decided to use vitamin C serum . I started using it 4 months now and my husband keeps looking at my face and saying : the product really suits you , i can see the difference : less dark spots on your face !
    i really liked the product the minute i used it because i felt no greasy, no sticky skin. On the contrary ; i feel my skin so smooth and the serum is perfectly absorbed in seconds . I use only the vitamin C serum , no cream , no lotion , nothing and i feel so happy . in few months i will turn 48 years old and my skin looks brighter .
    NB : for years i went to dermatologists who kept advising me different products to decrease the dark spots; unfortunately , i was never satisfied neither with the texture of the products nor with the results . As for advanced clinicals , i am quite sure i will keep buying from them and will advise people to do so .

  • Sunshine Original review: Mar 07, 2020. Reply

    It gave me a head ach just reading what was in products so I just started by buying a product in small quanities, trial sizes if I could find them. Got tired of the no results or the does the same or no difference except the price. I bought the retinol and collagen creams on a pump jar for at least 1/2 the price and I honestly love this stuff. I have been using this stuff and no other for about a year now and I do get compliments on how my skin looks. The wrinkles will always come and stay, that’s nature, but I’m convinced Advance Clinicals has helped and I will be buying more of the products. I’m going to be 66 in July and I’m happy with what I see.

  • C Original review: Feb 21, 2020. Reply

    I bought one of these products, Agevault Clinicals Tightening Collagen Anti-Aging Serum, because it was on clearance and had promising ingredients (HA, retinol, collagen, witch hazel, etc). I’m 22 with very dry skin and starting to get fine lines. Used the product daily for about 3 months and it’s almost out now. After applying, the fine lines were less visible, I assume due to the plumping effect of the hyaluronic acid. But in the long term, it didn’t do anything to permanently decrease my fine lines.

    While the effect on wrinkles is disappointing, it is a nice lightweight moisturizer. Easy to apply, not greasy, no fragrance (mild smell to wet product, goes away once it dries), and it does remove the “tight” feeling from my dry skin after applying.

    Not really sure what that “radiant” “bright” thing people talk about with skin is, so no comment on that. But it did make my face feel soft and look smooth (until the effect wore off of course).

  • CJ Welsh Original review: Aug 01, 2019. Reply

    I bought their Alpha Hydroxy Therapy Cream because I was looking for an aha cream that was affordable. I love it. I’ve been using it for about three months now and my skin is a lot smoother and refreshed. The only complaint I have is once I used about half the bottle, i had to remove the top because the pump stopped dispensing the product. Other than that, I loved it and would repurchase.

  • Guirlaine Brizard Original review: Jul 22, 2019. Reply

    I have been using these products for about 3 months. The Vitamin C, the Collagen and the Retinol. I am extremely satisfied. My skin is radiant and glowing. My colleagues always complimented me that I have the prettiest skin. Asking me what do I use and I am happy to share.

  • Linda McReynolds Original review: Dec 31, 2018. Reply

    I just recently purchased the Advanced Clinicals Vitamin C & Collagen serum, I also purchased the “Advanced Clinicals” hyaluronic acid moisturizer cream. I’ve only been using the products for 5 days. No major issues or changes as for now. Although my skin seems to be much smoother than before.?? So for now I’m going to continue using these 3 products along with my normal face routine. I’m hoping that in 4-6 weeks I can see a difference with my laugh line’s. I will try and remember to check back in, in 6 weeks. Until then I will be impatiently waiting on my laugh line’s to diminish soften or disappear.

  • Toni Original review: Aug 18, 2018. Reply

    i have been using the collagen serum for over a month now & I notice my face is radiant and starting to smooth out. I will be trying other products soon just want to see if this did anything for my complection first. Even started putting this on my hands too. So far so good….

  • Shania Claire Milano Original review: Jun 13, 2018. Reply

    I’ve been using the product , I think it was for eye serum and I bought it yesterday and I already saw the differences, my skin became smooth, and soft and refreshing. And I already suggest this to all my friends.

  • Lea Gordon Original review: Mar 10, 2018. Reply

    I have been using a few of these products for about 6 months. I am extremely satisfied with the results so far. I have purchased, the Hyaluuronic Serum, Eye Serum and Collagen and will continue to use the products. Many people have inquired about the products that I use, and I am always happy to share.

  • Sharon Macleod Original review: Jan 06, 2018. Reply

    I too was tired of promises. I found it on clearance,and thought,what the heck. From the minute I applied it,I felt a difference! Not kidding! We will see….it feels very refreshing!

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    User Rating: 4.3 (6 votes)

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