Advanced Clinicals Review



Advanced Clinicals is a “problem-solving” skin care line that was originally developed by chemists who wanted to create effective formulations using advanced technology. The brand’s mission is to offer skin care solutions at attainable prices for their customers, which is why all Advanced Clinicals skin care products retail for under $20. Knowing that advanced treatments for anti-aging, general skin care, as well as niche problem areas, like stretch marks and age spots, were often associated with a high price tag, Advanced Clinicals made it a priority to combat this with cost-effective, large-sized solutions in easy-to-dispense packaging. Advanced Clinicals is formulated in their own lab and manufactured in their own FDA-inspected facility in Chicago.


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-Advanced Clinicals


What’s Inside Advanced Clinicals Skin Care?

Here’s a closer look at the active ingredients commonly used in Advanced Clinicals skin care products. Vitamin C, peptides, and retinol make up the core ingredients for the Advanced Clinicals skin care line. These ingredients should all be part of your skincare routine.

Vitamin C
We’ve been hearing for years that Vitamin C is the best anti-aging ingredient. It’s a potent antioxidant that protects the skin from free radicals, the unstable molecules that contribute to the formation of premature wrinkles and fine lines on the skin.

Vitamin C also helps fade dark spots, evens out skin tone, and increases radiance. As if that wasn’t enough, research suggests that when vitamin C is applied to the skin, it significantly reverses aging-related structural changes by influencing collagen and elastin synthesis.

It’s in the Advanced Clinicals Vitamin C Brightening Serum, Vitamin C + Ferulic Acid Facial Mist, and Vitamin C Brightening Face and Body Cream. 

But our favorite Vitamin C serum is Carrot & Stick The Defence Serum. It contains 3 distinct types of Vitamin C that work together to help fight free radical damage. We recommend using it every morning.

As you age, your body’s production of collagen and elastin slows down. These two proteins are responsible for your skin’s structural support. As a result, the skin loses its natural plumpness and smoothness. 

While collagen is necessary for maintaining youthful-looking skin, the collagen protein is too large to absorb into the skin topically. That’s why applying skin care products that contain collagen won’t provide the anti-aging benefits you’re looking for.

This is where peptides come into action. Peptides are the building blocks of protein, and they are easily absorbed into the deeper layers of skin due to their smaller size. 

Advanced Clinicals Peptide Facial Serum is made with 6 peptides  to help reduce the look of premature aging and improve skin elasticity. 

If you’re looking for a peptide serum, we recommend Carrot & Stick The Repair Serum. It contains 7 plant-based peptides to promote plumper and smoother-looking skin. 

Retinol is the go-to anti-aging ingredient recommended by dermatologists and skin experts. It’s clinically proven to minimize the appearance of fine lines and wrinkles, improve uneven skin tone, restore skin firmness, and shrink the appearance of enlarged pores.

The only downside? Retinol can often lead to side effects like skin dryness, peeling, and irritation. 

It’s in the Advanced Clinicals Encapsulated Retinol Face Cream, Retinol Anti-Wrinkle Face Serum, and Retinol Anti-Aging Face and Body Cream. 

Use retinoids at night. We recommend this retinoid oil serum.  It contains Hydroxypinacolone Retinoate, an ingredient that provides similar benefits with less irritation.

Key products

Currently, Advanced Clinicals offers 50 different skin care products, including creams, lotions, oils, serums, problem-solvers, masks, and skin care for men. In this section, we’ll discuss three of the most popular Advanced Clinicals skin care products: Collagen Skin Rescue Lotion, Coconut Oil Moisturizing Cream, and Retinol Advanced Firming Cream. 

Advanced Clinicals Collagen Skin Rescue Lotion is a body and face moisturizer that is said to help promote soft, plump skin with consistent use. To use, apply a sufficient amount of lotion onto cleansed face, neck, and hands. Gently massage into skin using upward circular motions, paying special attention to the wrinkles, until fully absorbed.

Advanced Clinicals Coconut Oil Moisturizing Cream is a body and face moisturizer that is said to nourish and renew dull, parched skin for deep hydration. This cream absorbs quickly and does not leave a greasy feeling. Apply a generous amount onto cleansed face, neck, and hands. Gently massage into skin using upward circular motions, paying special attention to wrinkles.

Advanced Clinicals Retinol Advanced Firming Cream is a body and face moisturizer that is said to reduce the visible signs of aging as it helps replenish your moisture barrier. This retinol cream is gentle enough to be used daily. 

Key formulation

In order to find the formulation details for Advanced Clinicals skin care products, we had to search third party websites because the brand does not list the product ingredients on their website. Below we’ll discuss the formulation details for each of the key products mentioned above. 

Advanced Clinicals Collagen Skin Rescue Lotion contains a high concentration of mineral oil. Mineral oil is a clear, odorless oil derived from a mineral source, typically a distillate of petroleum, that functions as an emollient. After application, mineral oil forms a protective film on the surface of skin that helps to prevent evaporation of the skin’s natural moisture. Another key ingredient is hydrolyzed collagen. The term “hydrolyzed” means that the collagen protein has been broken down into amino acids so that this ingredient can better penetrate the skin. Hydrolyzed collagen is thought to replenish collagen levels in the skin that become depleted with age and from exposure to free radicals that degrade collagen. The result is skin that appears more firm and plump.

As the name implies, one of the key ingredients in the Advanced Clinicals Coconut Oil Moisturizing Cream is coconut oil. Coconut oil is an occlusive emollient, which means it forms a layer on the surface of skin to help lock in moisture. The fatty acids in coconut oil also help to replenish the skin’s barrier function. Lastly, the lauric acid found in coconut oil has antibacterial properties, which may be helpful for those with acne. Other beneficial ingredients in Advanced Clinicals Coconut Oil Moisturizing Cream include Aloe vera leaf juice, mineral oil, chamomile extract. 

Like the other two Advanced Clinicals moisturizers, the Retinol Advanced Firming Cream contains a high concentration of mineral oil to help keep the skin soft and smooth. This anti-aging cream also includes pure retinol. Retinol has the capability of minimizing the appearance of fine lines and wrinkles, improving uneven skin tone, restoring skin firmness, and shrinking the appearance of enlarged pores. Retinol provides all of these benefits by first being converted to retinoic acid (its active form) after being absorbed into the skin. Retinoic acid also functions as an antioxidant and helps the skin combat free radicals, the unstable molecules that contribute to the formation of premature wrinkles and fine lines on the skin. 

We’d like to point out one safety issue with Advanced Clinicals products: the brand uses the preservative DMDM hydantoin in several of their products. DMDM hydantoin is an antimicrobial formaldehyde releaser preservative that some consider to be unsafe because of the formaldehyde. While it has been approved safe by the Cosmetic Ingredient Review Expert Panel, this ingredient can cause irritation or an allergic reaction on sensitive skin.

Advanced Clinicals Reviews

It appears that Advanced Clinicals only includes a select few reviews on their website, and only positive reviews for that matter. For example, Advanced Clinicals reviews for the Retinol Advanced Firming Cream say things like “better than Neutrogena” and “Holy crap this stuff is GREAT.” Similar to their lack of transparency with the product formulations, it appears that Advanced Clinicals does not want to display all customer reviews for their products. 

What are some alternatives to Advanced Clinicals?

If you’re looking for skincare products to address the signs of aging, we recommend Carrot & Stick. Carrot & Stick maximizes the use of powerful ingredients and minimizes the use of superficial ones, resulting in advanced skincare solutions that help promote healthy, more youthful-looking skin. We recommend The Repair Serum, followed by The Moisturizer.



Carrot & Stick

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  • Ann Original review: Aug 24, 2021. Reply

    I started using the retinol serum, hyaluronic acid syrup, and the retinol cream 2 months ago. After about 3 weeks my assistant asked me what I was doing differently because I looked different. The fine lines around my eyes, forehead, and lip were vanishing. I am very happy so far. 2 recently tried the Vitamin C serum and the coq10 to see what these will do. I highly recommend this product line.

  • Heather Original review: Apr 06, 2021. Reply

    I started using Advanced clinicals Vitamin c cream and some of their serums and I love them! They improve my skin but don’t break me out or dry me out. I have very sensitive skin and these products work well for me. Also they are inexpensive.

  • meryem Original review: Jan 25, 2021. Reply

    i got across advanced clinicals just by chance and i decided to use vitamin C serum . I started using it 4 months now and my husband keeps looking at my face and saying : the product really suits you , i can see the difference : less dark spots on your face !
    i really liked the product the minute i used it because i felt no greasy, no sticky skin. On the contrary ; i feel my skin so smooth and the serum is perfectly absorbed in seconds . I use only the vitamin C serum , no cream , no lotion , nothing and i feel so happy . in few months i will turn 48 years old and my skin looks brighter .
    NB : for years i went to dermatologists who kept advising me different products to decrease the dark spots; unfortunately , i was never satisfied neither with the texture of the products nor with the results . As for advanced clinicals , i am quite sure i will keep buying from them and will advise people to do so .

  • Sunshine Original review: Mar 07, 2020. Reply

    It gave me a head ach just reading what was in products so I just started by buying a product in small quanities, trial sizes if I could find them. Got tired of the no results or the does the same or no difference except the price. I bought the retinol and collagen creams on a pump jar for at least 1/2 the price and I honestly love this stuff. I have been using this stuff and no other for about a year now and I do get compliments on how my skin looks. The wrinkles will always come and stay, that’s nature, but I’m convinced Advance Clinicals has helped and I will be buying more of the products. I’m going to be 66 in July and I’m happy with what I see.

  • C Original review: Feb 21, 2020. Reply

    I bought one of these products, Agevault Clinicals Tightening Collagen Anti-Aging Serum, because it was on clearance and had promising ingredients (HA, retinol, collagen, witch hazel, etc). I’m 22 with very dry skin and starting to get fine lines. Used the product daily for about 3 months and it’s almost out now. After applying, the fine lines were less visible, I assume due to the plumping effect of the hyaluronic acid. But in the long term, it didn’t do anything to permanently decrease my fine lines.

    While the effect on wrinkles is disappointing, it is a nice lightweight moisturizer. Easy to apply, not greasy, no fragrance (mild smell to wet product, goes away once it dries), and it does remove the “tight” feeling from my dry skin after applying.

    Not really sure what that “radiant” “bright” thing people talk about with skin is, so no comment on that. But it did make my face feel soft and look smooth (until the effect wore off of course).

  • CJ Welsh Original review: Aug 01, 2019. Reply

    I bought their Alpha Hydroxy Therapy Cream because I was looking for an aha cream that was affordable. I love it. I’ve been using it for about three months now and my skin is a lot smoother and refreshed. The only complaint I have is once I used about half the bottle, i had to remove the top because the pump stopped dispensing the product. Other than that, I loved it and would repurchase.

  • Guirlaine Brizard Original review: Jul 22, 2019. Reply

    I have been using these products for about 3 months. The Vitamin C, the Collagen and the Retinol. I am extremely satisfied. My skin is radiant and glowing. My colleagues always complimented me that I have the prettiest skin. Asking me what do I use and I am happy to share.

  • Linda McReynolds Original review: Dec 31, 2018. Reply

    I just recently purchased the Advanced Clinicals Vitamin C & Collagen serum, I also purchased the “Advanced Clinicals” hyaluronic acid moisturizer cream. I’ve only been using the products for 5 days. No major issues or changes as for now. Although my skin seems to be much smoother than before.?? So for now I’m going to continue using these 3 products along with my normal face routine. I’m hoping that in 4-6 weeks I can see a difference with my laugh line’s. I will try and remember to check back in, in 6 weeks. Until then I will be impatiently waiting on my laugh line’s to diminish soften or disappear.

  • Toni Original review: Aug 18, 2018. Reply

    i have been using the collagen serum for over a month now & I notice my face is radiant and starting to smooth out. I will be trying other products soon just want to see if this did anything for my complection first. Even started putting this on my hands too. So far so good….

  • Shania Claire Milano Original review: Jun 13, 2018. Reply

    I’ve been using the product , I think it was for eye serum and I bought it yesterday and I already saw the differences, my skin became smooth, and soft and refreshing. And I already suggest this to all my friends.

  • Lea Gordon Original review: Mar 10, 2018. Reply

    I have been using a few of these products for about 6 months. I am extremely satisfied with the results so far. I have purchased, the Hyaluuronic Serum, Eye Serum and Collagen and will continue to use the products. Many people have inquired about the products that I use, and I am always happy to share.

  • Sharon Macleod Original review: Jan 06, 2018. Reply

    I too was tired of promises. I found it on clearance,and thought,what the heck. From the minute I applied it,I felt a difference! Not kidding! We will see….it feels very refreshing!

  • Your Review
    User Rating: 4.4 (7 votes)

    Advanced Clinicals Collagen Skin Rescue Lotion Review

    A hydrating face and body lotion formulated with Glycerin, Aloe and Mineral Oil. The product also contains hydrolyzed collagen (also known as collagen hydrolysate), which is typically derived from animal by-products. We This product is affordable and can be purchased at Walmart, Seas and Jet.

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