Equelle Review: A Hormone-Free Solution to Menopause Symptoms?



Sold by Pharmavite, Equelle is a hormone-free, non-prescription dietary supplement that’s claimed to provide symptom relief due to estrogen decline during menopause. 

According to the brand, Equelle can help to decrease the frequency of hot flashes, reduce vaginal irritation, support sleep quality, and alleviate mood swings. 

Further reading: Best supplements 2024.

So does Equelle live up to these claims? To answer that question, we’ll thoroughly review the product formulation based on what the current medical research has found about the benefits of the ingredients in the formulation. 

We’ll also share some Equelle reviews so that you can get an idea of what customers really think of these products. 

What Are The Equelle Ingredients?

There’s just one key ingredient in the Equelle formula and that’s S-equol. So what exactly is S-equol?

S-equol is a non-hormonal compound that can be produced naturally in the human body in certain individuals. 

According to the Journal of Women’s Health, S-equol is an intestinal bacterial metabolite of the soybean isoflavone daidzein. About 50% of Asians and 25% of non-Asians host the intestinal bacteria that convert daidzein into S-equol. 

The women who are able to produce S-equol in their own bodies after eating soy experience more mild menopause symptoms as a result. 

By understanding the association between S-equol production and reduced menopausal symptoms, researchers have explored the possibility of using S-equol supplementation to provide relief for women experiencing menopausal symptoms. 

That’s where Equelle comes into the picture. 

The S-equol used in the Equelle supplement is produced through the brand’s patented soy germ fermentation process. 

S-equol shares a similar molecular structure to estrogen, allowing it to bind to the body’s estrogen receptors and mimic the effects of estrogen.

The theory is that as estrogen declines, menopause symptoms go up. S-equol acts like estrogen in your body to help decrease menopause symptoms. 

A publication in the journal Nutrition Reviews explains that in intervention studies in which plasma S-equol levels were determined, a concentration of >5-10 ng/mL has been associated with a positive outcome for vasomotor symptoms of menopause (hot flashes and night sweats). 

A randomized trial published in Menopause, the journal of the North American Menopause Society, investigated the effects of an S-equol supplement on menopausal symptoms and mood states among Japanese women aged 40 to 59 years. 

The study found that the group receiving 10 mg of equol three times per day showed significant improvements in mood-related symptoms, including decreased depression scores and increased vigor, compared to the placebo group. 

It’s also important to note that Equelle and its active ingredient, S-equol, have undergone decades of clinical research and development. It has been shown to be safe and is not associated with changes in sex or thyroid hormones, negative effects on endometrial health or breast cancer. 

What Are The Benefits of Equelle?

After reviewing the research on S-equol, we’ve summarized the following benefits that Equelle may offer:

Alleviate Hot Flashes and Night Sweats

S-equol has been shown in several clinical studies to alleviate the vasomotor symptoms of menopause, including hot flashes and night sweats. We also read many Equelle reviews from customers who experienced these benefits. 

Improved Mood

Another benefit of Equelle that was seen in the clinical studies was an improvement in mood-related symptoms, such as anxiety and depression. 

Better Sleep

Research suggests that S-equol may improve sleep quality by modulating hormonal levels and neurotransmitter activity, thereby promoting relaxation and reducing symptoms of anxiety and stress that can interfere with sleep. 

Additionally, S-equol indirectly helps with sleep by alleviating hot flashes and night sweats, which in turn reduces disruptions and discomfort during the night.

What Are The Equelle Side Effects?

Like any dietary supplement, there is a possibility of experiencing side effects. 

The brand’s website states that some individuals have reported gastrointestinal side effects when taking Equelle, and they can subside after a few days to a week of taking the product. It can also help to take Equelle with food.

Always consult with your healthcare provider before incorporating any supplements into your routine to ensure they align with your individual health needs and medical conditions.

Does Equelle Cause Weight Gain?

The brand’s website does not mention that Equelle can cause weight gain. Furthermore, the studies on S-equol primarily focus on its potential benefits in alleviating menopausal symptoms rather than its effects on weight.

However, we read a couple Equelle reviews that mentioned weight gain while taking this supplement. 

Where to Buy Equelle?

Equelle is sold exclusively on the brand’s website ( 

How Much is Equelle?

Equelle costs $50 USD for one bottle (30 day supply). 

What is The Equelle Return Policy?

There’s a 90 day money back guarantee when you purchase Equelle. The policy states, “We want you to be happy with Equelle. If Equelle doesn’t work for you, we’ll make it easy and refund you in full. Our 90-day money-back guarantee covers up to 3 bottles if you have not found relief by the end of your third month.”

Equelle Reviews

Equelle reviews on the brand’s website are overall very positive. There are many 5-star reviews from customers who confirm that it really helps to reduce the frequency and severity of hot flashes while also promoting better sleep. 

For example, one review says, “I have tried numerous over the counter menopause relief supplements. Equelle is by far my favorite and the only one that I have stayed with because it works. I sleep better, and seldom have hot flashes.”

And another 5-star review says, “I finally feel like myself again. Besides feeling like myself I haven’t really had hot flashes either and I’m sleeping better.”

However, there are a handful of negative reviews for the Equelle, which are mostly from customers who were disappointed that they didn’t see the results they were hoping for with this product. 

For example, one review says, “Into my second bottle and I haven’t noticed any difference in hot flashes or night sweats. This doesn’t work for me.”

Another 1-star review says, “Literally had 0 effect on hot flashes. I gained 5 pounds on it and within 3 days of not using this the 5 pounds were gone.”

Our Verdict

After reviewing the research on S-equol, it’s clear that this compound may have positive effects on menopausal symptoms, including alleviating hot flashes and night sweats, improving mood, and promoting better sleep. 


  • Research supports the benefits of S-equol (the key ingredient in Equelle)
  • The brand reports that it has been shown to be safe and is not associated with changes in sex or thyroid hormones, negative effects on endometrial health or breast cancer. 
  • Many positive Equelle reviews
  • 90-day money-back guarantee


  • Some reviews mention that the product didn’t work

What Are Some Alternatives to Equelle?

If you’re looking for an alternative to Equelle, below we’ll link to reviews we’ve written for supplements that are formulated specifically for menopausal symptoms:

  • Provitalize Review: Provitalize is a probiotic supplement formulated specifically for menopausal women. It’s said to naturally manage abdominal fat during menopause, as well as improve digestion, ease hot flashes, support joint health, increase energy, and more. 
  • Happy Mammoth Hormone Harmony Review: Hormone Harmony is a supplement that promises to support hormonal balance in women during all stages, from premenstrual symptoms to menopause symptoms. It’s said to offer benefits beyond just alleviating symptoms, such as improving sleep quality, increasing energy, curbing carb cravings, and even promoting healthy weight loss. 

Nutr Rev. 2011 Aug;69(8):432-48.
J Womens Health (Larchmt). 2015 Mar;24(3):200-8.
Menopause. 2009 Jan-Feb;16(1):141-8.



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