Gundry MD Bio Complete 3 Review



Bio Complete 3 is a digestive-support supplement sold by Gundry MD, the brand of health and wellness products by cardiologist Dr. Steven Gundry. 

Formulated with a “3-pronged blend” of probiotics, prebiotics, and postbiotics, Bio Complete 3 is said to provide numerous benefits, such as helping you maintain a healthy weight, support better digestion, better focus, increased energy levels, and even a more radiant complexion. 

Further reading: Best supplements 2024.

So does Gundry MD Bio Complete 3 live up to these claims? To answer that question, we’ll thoroughly review the product formulation based on what the current medical research has found about the benefits of these ingredients. 

We’ll also share some Bio Complete 3 reviews from real customers so that you can get their take on the results of this supplement. 

What Are The Gundry MD Bio Complete 3 Ingredients?

The Bio Complete 3 formulation contains a “3-pronged blend” of prebiotics, probiotics, and postbiotics. Below we’ll give you the details on each one. 

Prebiotic Blend

Prebiotics are non-digestible fibers that serve as “food” for the beneficial bacteria in the gut, thereby promoting digestive health. 

There’s two prebiotics in Bio Complete 3: Acacia Gum (from Corebiome) and SunFiber Guar Fiber. 

An 2021 in vitro (test tube) study published in the journal ACS Omega found that acacia gum “significantly promotes Bifidobacteria proliferation similar to fructo-oligosaccharides (FOS) while inhibiting the Clostridium histolyticum group, commonly associated with gut dysbiosis.”

In simpler terms, this means acacia gum helped the good bacteria (Bifidobacteria) grow, and stopped the bad bacteria (Clostridium group) that can cause problems in the gut.

The other prebiotic in Bio Complete 3 is SunFiber, a patented fiber derived from guar gum. There are some studies that demonstrate the health benefits of guar gum. 

For example, in a 2023 study published in the Journal of Clinical Biochemistry and Nutrition, participants took 3 to 5 grams (g) of partially hydrolyzed guar gum dietary fiber. Results of this study found that guar gum improved gut health, sleep, and motivation among healthy subjects. 

However, we noticed there’s a very low dose of guar gum in the Bio Complete 3 formula. 

While we don’t know the exact amount in Bio Complete 3, the label states that the total combined amount of acacia gum and guar gum is only 450 mg — so that means the amount of guar gum is significantly lower than the dosage used in the aforementioned study. 

Probiotic Blend

Probiotics are live beneficial bacteria that support the balance of the gut microbiome, aiding in the digestion and absorption of nutrients. They can contribute to a healthy and balanced gut environment.

There’s two probiotic strains inside Bio Complete 3: Bacillus Coagulans (ProDura) and Bifidobacterium bifidum. 

ProDura is a patented strain of the probiotic Bacillus coagulans. ProDura, being a spore-forming bacterium, is believed to retain a natural protective coating that remains inactive until it encounters the suitable conditions of heat, pH, and moisture in the large intestine.

  1. coagulans has been studied in both animal and human trials. Results of these trials suggest that this probiotic may help with IBS, constipation, and intestinal gas. 

Bifidobacterium is one of the most common probiotics found in the human gut, and supplementing with this probiotic may offer several benefits. 

For example, a 2021 publication in the journal Frontiers in Bioengineering and Biotechnology shares that Bifidobacterium may help reduce inflammation, help the body fight infection, relieve constipation, and alleviate symptoms of lactose intolerance.

Postbiotic Blend

The postbiotic in Bio Complete 3 is called tributyrin, a triglyceride composed of three butyrate molecules. Butyrate is a short-chain fatty acid that serves as an important energy source for the cells lining the colon.

According to a 2023 publication in the peer-reviewed journal PLOS One, tributyrin “has a key role in anti-inflammatory and intestinal barrier repair effects by slowly releasing butyric acid”.

What Are The Benefits of Gundry MD Bio Complete 3?

After reviewing the various ingredients and probiotics used in Gundry MD Bio Complete 3, we’ve summarized the benefits you may notice with this product:

Balanced Microbiome

The purpose of the pre- and probiotics in Bio Complete 3 is to help maintain the balance of the gut microbiome by preventing the overgrowth of “bad” bacteria. A balanced gut microbiome is crucial for maintaining overall health, supporting digestion, immune function, and even mental well-being.

Reduce Intestinal Inflammation

The inclusion of the postbiotic tributyrin in Bio Complete 3 may help to reduce intestinal inflammation and promote intestinal barrier repair. Ultimately, this means it may help alleviate discomfort, promote proper nutrient absorption, and support overall gut health.

What Are The Side Effects of Bio Complete 3?

Like any dietary supplement, there is a possibility of experiencing side effects. 

The side effects that are typically associated with pre- and probiotic supplements include stomach upset, gas, diarrhea, or bloating. Based on the Bio Complete 3 reviews that we read, there are customers who have experienced these side effects from this product.

Always consult with your healthcare provider before incorporating any supplements into your routine to ensure they align with your individual health needs and medical conditions.

Where to Buy Gundry MD Bio Complete 3?

Gundry MD Bio Complete 3 is sold on the brand’s website (, as well as on 

How Much is Gundry MD Bio Complete 3?

On the brand’s website, Bio Complete 3 costs $69.95 USD for a 30 day supply (the member price is $49.95). 

On, Bio Complete 3 costs $51.26 for the same amount.

What is The Gundry MD Return Policy?

The Gundry MD return policy states, “We offer a 90-Day Money Back guarantee on all Products purchased through our Website. Your guarantee comes into effect on the day your Product is shipped from our fulfillment center, and expires ninety (90) days after the shipped date.”

Gundry MD Bio Complete 3 Reviews

In our opinion, Amazon provides a more reliable source for genuine customer reviews compared to a brand’s official website.

On, Gundry MD Bio Complete 3 has earned an average rating of 3.9 out of 5 stars after 5,000 customer reviews. 

There are many 5-star reviews for Gundry MD Bio Complete 3 from customers who love that it improves digestion, promotes regular bowel movements, and helps with energy levels. 

For example, one review says, “I’ve been taking the product for a little over a week and I can honestly say it’s working for me no more trouble with bowel movements..The capsule are very easy to swallow.”

And another 5-star review says, “I like this product. I’ve only taken them for about a month and my tummy problems have been better and I am even resting better.”

However, there are a handful of negative reviews for the Gundry MD Bio Complete 3, which are mostly from customers who experienced side effects after starting this supplement. 

For example, one review says, “Tummy trouble – have taken a number of pre- and probiotics over the year and never had tummy trouble. This one caused me to have to stay home for 3 days before I returned to normal. 

Another 1-star review says, “I haven’t been able to go to the bathroom correctly since I started using this stuff. I got to the point where I just needed to quit and finally I’m back on some sort of a regular schedule.”

Our Verdict

While there are beneficial ingredients in Bio Complete 3, many of them are used in low doses that may not be effective. 


  • All of the ingredients have research to support their gut health benefits
  • Many positive Gundry MD Bio Complete 3 reviews
  • 90-Day Money Back guarantee


  • Most of the ingredients are used in very low doses
  • Some reviews side effects like upset stomach and irregular bowel movements

What Are Some Alternatives to Bio Complete 3?

If you’re looking for alternatives to Gundry MD Bio Complete 3, check out our reviews for these gut supportive supplements:

  • Align Probiotics Review: Align is a brand that offers a variety of supplements to help support your gut health and daily wellness.
  • Activated You Morning Complete: Morning Complete is formulated with a custom-selected blend of nutrients designed to support regular digestive function, daily energy levels, and overall wellness. 
  • Gundry MD Total Restore: Formulated with 20 pro-digestive ingredients, Total Restore is claimed to be “scientifically shown to support a strong, healthy gut lining” and, therefore, provide benefits such as promoting smooth digestion, comfortable bowel movements, curbing unhealthy cravings for junk food, increased energy, and more. 

ACS Omega. 2021 Jul 20; 6(28): 17782–17797.
PLoS One. 2023 Jul 31;18(7):e0289364
J Clin Biochem Nutr. 2023 Mar; 72(2): 189–197.
Front Bioeng Biotechnol. 2021; 9: 770248.



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